公开(公告)号：US12202899B2

公开(公告)日：2025-01-21

申请号：US17256999

申请日：2019-07-14

Applicant: Development Center for Biotechnology

Inventor： Cheng-Chou Yu ,  Shih-Rang Yang ,  Tsung-Han Hsieh ,  Mei-Chi Chan ,  Shu-Ping Yeh ,  Chuan-Lung Hsu ,  Ling-Yueh Hu ,  Chih-Lun Hsiao

IPC: C07K16/28 ,  A61K47/68

Abstract: An anti-PD-L1 antibody, or an antigen-binding fragment thereof, comprising: a heavy chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 2-4, 6-8, 10-12, 14-16, or 18-20; and/or a light chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 22-24, 26-28, 30-32, 34-36, or 38-40, wherein the antibody is a chimeric, humanized, composite, or human antibody.