公开(公告)号：US20250066793A1

公开(公告)日：2025-02-27

申请号：US18724758

申请日：2022-12-28

Applicant: Development Center for Biotechnology

Inventor： Ying-Shuan LAILEE ,  Chia-Wei LIU ,  Chi-Tang WANG ,  Pei-Yi TSAI ,  Chung-Hsiun WU ,  King LAM ,  Wei-Ting SUN ,  Kai-Chien YANG ,  Hung-Jyun HUANG

IPC: C12N15/113 ,  A61P11/00

Abstract: Disclosed herein are novel single-stranded anti-sense oligonucleotides (ASOs) capable of reducing the transcription of thioredoxin domain containing protein 5 (TXNDC5) mRNA. Also disclosed is use of the single-stranded ASOs as disclosed herein for manufacturing medicaments suitable for treating a disease associated with upregulation of TXNDC5. Accordingly, a pharmaceutical composition comprising the disclosed ASO molecules is provided; as well as a method of treating a subject suffering from TXNDC5-mediated disease via administering to the subject the disclosed single-stranded ASO molecules.