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    Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
    3.
    发明授权
    Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring 有权
    具有2,5-取代的恶唑并嘧啶环的羧酸衍生物

    公开(公告)号：US08846692B2

    公开(公告)日：2014-09-30

    申请号：US13521831

    申请日：2011-01-12

    申请人： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    发明人： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D279/00 ,  C07D498/04

    CPC分类号： C07D498/04

    摘要： The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3 and X are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

    摘要翻译： 本发明涉及式I的恶唑并嘧啶化合物，其中A，R 1，R 2，R 3和X如权利要求中所定义。 式I的化合物调节Edg-1受体的活性，特别是该受体的激动剂，并且可用于例如治疗动脉粥样硬化，心力衰竭或外周动脉闭塞性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物组合物。

    Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
    4.
    发明授权
    Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring 有权
    具有2,5-取代的恶唑并嘧啶环的杂环羧酸衍生物

    公开(公告)号：US08846690B2

    公开(公告)日：2014-09-30

    申请号：US13521828

    申请日：2011-01-12

    申请人： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    发明人： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D239/00 ,  C07D498/04

    CPC分类号： C07D498/04

    摘要： Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonistsThe present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

    摘要翻译： 包含2,5-取代的恶唑啉嘧啶环作为Edg-1受体激动剂的杂环羧酸衍生物本发明涉及式I的恶唑并嘧啶化合物，其中A，R 1，R 2，R 3，X和Y如 声称。 式I的化合物调节Edg-1受体的活性，特别是该受体的激动剂，并且可用于例如治疗动脉粥样硬化，心力衰竭或外周动脉闭塞性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物组合物。

    HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING
    9.
    发明申请
    HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING 有权
    具有2,5-取代的氧杂环糊精环的杂环羧酸衍生物

    公开(公告)号：US20130072502A1

    公开(公告)日：2013-03-21

    申请号：US13521828

    申请日：2011-01-12

    申请人： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    发明人： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    IPC分类号： C07D498/04

    CPC分类号： C07D498/04

    摘要： Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonistsThe present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

    摘要翻译： 包含2,5-取代的恶唑啉嘧啶环作为Edg-1受体激动剂的杂环羧酸衍生物本发明涉及式I的恶唑并嘧啶化合物，其中A，R 1，R 2，R 3，X和Y如 声称。 式I的化合物调节Edg-1受体的活性，特别是该受体的激动剂，并且可用于例如治疗动脉粥样硬化，心力衰竭或外周动脉闭塞性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物组合物。