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公开(公告)号:US20100310659A1
公开(公告)日:2010-12-09
申请号:US12752035
申请日:2010-03-31
申请人: Dipen Desai , Ralph Diodone , Zenaida Go , Prabha N. Ibrahim , Raman Iyer , Hans-Juergen Mair , Harpreet K. Sandhu , Navnit H. Shah , Gary Visor , Nicole Wyttenbach , Stephan Lauper , Johannes Pudewell , Frank Wierschem
发明人: Dipen Desai , Ralph Diodone , Zenaida Go , Prabha N. Ibrahim , Raman Iyer , Hans-Juergen Mair , Harpreet K. Sandhu , Navnit H. Shah , Gary Visor , Nicole Wyttenbach , Stephan Lauper , Johannes Pudewell , Frank Wierschem
IPC分类号: A61K9/14 , C07D471/04 , A61K31/437
CPC分类号: C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
摘要翻译: 提供的是固体分散体,固体分子复合物,盐和结晶多晶型物,其涉及丙烷-1-磺酸{3- [5-(4-氯 - 苯基)-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟 - 苯基} - 酰胺。
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公开(公告)号:US09447089B2
公开(公告)日:2016-09-20
申请号:US12752035
申请日:2010-03-31
申请人: Dipen Desai , Ralph Diodone , Zenaida Go , Prabha N. Ibrahim , Raman Iyer , Hans-Juergen Mair , Harpreet K. Sandhu , Navnit H. Shah , Gary Visor , Nicole Wyttenbach , Stephan Lauper , Johannes Pudewell , Frank Wierschem
发明人: Dipen Desai , Ralph Diodone , Zenaida Go , Prabha N. Ibrahim , Raman Iyer , Hans-Juergen Mair , Harpreet K. Sandhu , Navnit H. Shah , Gary Visor , Nicole Wyttenbach , Stephan Lauper , Johannes Pudewell , Frank Wierschem
IPC分类号: A61K9/14 , C07D471/04 , A61K31/437 , A61K9/10 , A61K9/16 , A61K9/00
CPC分类号: C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
摘要翻译: 提供的是固体分散体,固体分子复合物,盐和结晶多晶型物,其涉及丙烷-1-磺酸{3- [5-(4-氯 - 苯基)-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟 - 苯基} - 酰胺。
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公开(公告)号:US20110112136A1
公开(公告)日:2011-05-12
申请号:US12941127
申请日:2010-11-08
IPC分类号: A61K31/437 , A61P35/00
CPC分类号: C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要: The present invention is related to an improved method for the manufacture of Micro-precipitated Bulk Powder (MBP) containing the active pharmaceutical ingredient Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS). The invention is further directed to pharmaceutical compositions containing said MBP, as well as its use in the manufacture of medicaments for the treatment of cancer.
摘要翻译: 本发明涉及一种制备含有活性药物成分丙烷-1-磺酸{3- [5-(4-氯 - 苯基)-1H-吡咯并[ 2,3-b]吡啶-3-羰基] -2,4-二氟 - 苯基} - 酰胺和羟丙基甲基纤维素醋酸琥珀酸酯(HPMCAS)。 本发明还涉及含有所述MBP的药物组合物,以及其在制备用于治疗癌症的药物中的用途。
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