公开(公告)号：US20050255043A1

公开(公告)日：2005-11-17

申请号：US11102191

申请日：2005-04-08

申请人： Donald Hnatowich ,  Mary Rusckowski

发明人： Donald Hnatowich ,  Mary Rusckowski

IPC分类号： A61K49/00 ,  A61K51/12 ,  C12Q1/70

CPC分类号： A61K51/1203

摘要： Labeled bacteriophage are disclosed which are useful for detecting a bacterial infection in vivo.

摘要翻译： 公开了用于检测体内细菌感染的标记噬菌体。

公开(公告)号：US4668503A

公开(公告)日：1987-05-26

申请号：US590833

申请日：1984-03-19

申请人： Donald Hnatowich

发明人： Donald Hnatowich

IPC分类号： A61K51/08 ,  A61K51/10 ,  A61K43/00 ,  A61K39/00 ,  A61K49/02

CPC分类号： A61K51/088 ,  A61K51/048 ,  A61K51/1093 ,  A61K2121/00 ,  A61K2123/00

摘要： Amines, including proteins and polypeptides covalently coupled with a chelating agent such as diethylenetriaminepentaacetic acid (DTPA) can be labeled with .sup.99m Tc in the presence of a stannous reducing agent at near neutral pH by maintaining the protein concentration at a low level and the DTPA concentration at a high level. The .sup.99m Tc is labeled to the protein through the DTPA sites linked to the protein. Utilizing .sup.111 In labeled proteins as controls, it is shown that the .sup.99m Tc labeled proteins are labeled at the DTPA sites and that they exhibit in vivo stabilities equal to that of the .sup.111 In labeled proteins.

摘要翻译： 与螯合剂如二亚乙基三胺五乙酸（DTPA）共价偶联的胺可以在接近中性pH的亚锡还原剂存在下用99mTc标记，通过将蛋白质浓度保持在低水平，DTPA浓度在 高水平 通过与蛋白质连接的DTPA位点将99mTc标记为蛋白质。 利用111In标记的蛋白质作为对照，显示99mTc标记的蛋白质在DTPA位点被标记，并且它们的体内稳定性显示与111In标记的蛋白质相同的体内稳定性。