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1.发明申请公开(公告)号：US20090325920A1
公开(公告)日：2009-12-31
申请号：US11909278
申请日：2006-03-24
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译： 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。
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2.发明申请公开(公告)号：US20050187188A1
公开(公告)日：2005-08-25
申请号：US11085889
申请日：2005-03-22
申请人： Donald Stein , Stuart Hoffman
发明人： Donald Stein , Stuart Hoffman
IPC分类号： A61K47/40 , A61K31/57 , A61P7/10 , A61P17/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61K31/724
CPC分类号： A61K31/57
摘要： The present invention provides methods for conferring a neuroprotective effect on a population of cells in a subject following a traumatic injury to the central nervous system. Specifically, the methods of the invention provide for the administration of a progestin or progestin metabolite following a traumatic brain injury. The progestin or progestin metabolite is administered at therapeutically effective concentrations that produce a neuroprotective effect (i.e., a decrease in the loss of neuronal activity) and reduces and/or prevents the various physiological events leading to neurodegeneration, such as, cerebral edema and the immune/inflammatory response.
摘要翻译： 本发明提供了对中枢神经系统创伤性损伤后对受试者的细胞群赋予神经保护作用的方法。 具体地，本发明的方法提供了在创伤性脑损伤后给药孕激素或孕激素代谢物。 孕激素或孕激素代谢物以治疗有效浓度施用，其产生神经保护作用（即，神经元活性丧失的减少），并且减少和/或预防导致神经变性的各种生理事件，例如脑水肿和免疫 /炎症反应。
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3.发明申请公开(公告)号：US20120245133A1
公开(公告)日：2012-09-27
申请号：US13454503
申请日：2012-04-24
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译： 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。
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公开(公告)号：US20070078117A1
公开(公告)日：2007-04-05
申请号：US11527816
申请日：2006-09-27
IPC分类号： A61K31/57
CPC分类号： A61K31/57
摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
摘要翻译： 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。
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