公开(公告)号：US20120237522A1

公开(公告)日：2012-09-20

申请号：US13398915

申请日：2012-02-17

Applicant: Chang Yuil KANG ,  Woo Sung CHANG ,  Ji Yeon KIM ,  Dong-Hyeon KIM

Inventor： Chang Yuil KANG ,  Woo Sung CHANG ,  Ji Yeon KIM ,  Dong-Hyeon KIM

IPC: A61K39/395 ,  A61P35/02 ,  A61P35/00

CPC classification number: C07K16/2818 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2827 ,  C07K2317/76 ,  A61K2300/00

Abstract: Provided is an anticancer agent which comprises an anti-PD-1 antibody or an anti-PD-L1 antibody as an active ingredient, functioning to reverse the unresponsiveness of iNKT cells in which anergy has been induced by administration with an iNKT cell ligand. The anti-PD-1 or anti-PD-L1 antibody blocks the PD-1/PD-L1-mediated signaling pathway not only to prevent the iNKT cell ligand-induced iNKT cell anergy, but also to reverse the unresponsiveness of already anergic iNKT cells to produce cytokines. In addition, the anti-PD1 or anti-PD-L1 antibody ensures the potent anti-tumor activity of iNKT cells as demonstrated by a significant reduction in the number of metastatic nodules in B16F10 melanoma metastasis models in vivo. Collectively, the anticancer agent can be very useful in the treatment of cancer, particularly metastatic cancer.

Abstract translation: 提供一种抗癌剂，其包含抗PD-1抗体或抗-PD-L1抗体作为活性成分，其功能是通过用iNKT细胞配体施用而逆转已经诱导了无能力的iNKT细胞的无反应性。 抗PD-1或抗PD-L1抗体阻断PD-1 / PD-L1介导的信号通路，不仅可以防止iNKT细胞配体诱导的iNKT细胞无反应，而且可以逆转已经无能的iNKT的无反应性 细胞产生细胞因子。 此外，抗PD1或抗PD-L1抗体确保iNKT细胞的有效的抗肿瘤活性，如通过体内B16F10黑素瘤转移模型中转移性结节数量的显着减少所证实的。 总的来说，抗癌剂在治疗癌症，特别是转移性癌症中是非常有用的。

公开(公告)号：US20110235726A1

公开(公告)日：2011-09-29

申请号：US13070943

申请日：2011-03-24

Applicant: Dong-Hyeon KIM

Inventor： Dong-Hyeon KIM

IPC: H04L27/00

CPC classification number: H04L5/0085 ,  H04L5/0096

Abstract: An apparatus and method for updating channel information in a mobile communication terminal supporting Digital Multimedia Broadcasting (DMB) are provided. The method includes sending a broadcasting information request to an Over The Air (OTA) server over a mobile communication network, receiving broadcasting information from the OTA server over the mobile communication network, and updating stored broadcasting information based on the received broadcasting information.

Abstract translation: 提供了一种在支持数字多媒体广播（DMB）的移动通信终端中更新频道信息的装置和方法。 该方法包括通过移动通信网络向空中（OTA）服务器发送广播信息请求，通过移动通信网络从OTA服务器接收广播信息，并且基于接收到的广播信息更新存储的广播信息。

公开(公告)号：US20100190527A1

公开(公告)日：2010-07-29

申请号：US12691870

申请日：2010-01-22

Applicant: Dong-Hyeon KIM

Inventor： Dong-Hyeon KIM

IPC: H04M1/00 ,  G06F3/00

CPC classification number: H04N7/147

Abstract: An apparatus and a method for a peripheral device control in a portable terminal are provided. In the method for the peripheral device control in the portable terminal, the method includes selectively changing a communication path between a communication modem and a storage to a communication path between a controller and the storage by controlling a switch when the communication modem is turned off, determining information necessary for the peripheral device control through the communication path between the controller and the storage and controlling the peripheral device when the information satisfies a control condition.

Abstract translation: 提供了一种用于便携式终端中的外围设备控制的装置和方法。 在便携式终端中的外围设备控制方法中，该方法包括：当通信调制解调器关闭时，通过控制开关来选择性地将通信调制解调器和存储器之间的通信路径改变为控制器与存储器之间的通信路径， 通过控制器和存储器之间的通信路径确定外围设备控制所需的信息，并且当信息满足控制条件时控制外围设备。