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47 条记录 (耗时 0.042 秒)

    CGRP RECEPTOR ANTAGONISTS
    3.
    发明申请
    CGRP RECEPTOR ANTAGONISTS 审中-公开
    CGRP受体拮抗剂

    公开(公告)号：US20110245240A1

    公开(公告)日：2011-10-06

    申请号：US13122769

    申请日：2009-09-30

    申请人： Donnette D. Staas ,  Ian M. Bell ,  Michael R. Wood

    发明人： Donnette D. Staas ,  Ian M. Bell ,  Michael R. Wood

    IPC分类号： A61K31/538 ,  C07D491/20 ,  C07D471/04 ,  C07D491/107 ,  A61K31/499 ,  A61K31/437 ,  A61K31/438 ,  A61P25/00 ,  A61P25/06

    CPC分类号： A61K31/00 ,  C07D471/10 ,  C07D491/107 ,  C07D491/20

    摘要： Compounds of Formula (I): (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

    摘要翻译： 式（I）的化合物（其中变量A1，A2，A3，A4，A5，A6，A7，A8，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf，RPG和Y和 Z如本文所述）可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

    3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
    5.
    发明授权
    3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists 有权
    具有N-连接的杂环CGRP受体拮抗剂的3-和6-喹啉

    公开(公告)号：US08507477B2

    公开(公告)日：2013-08-13

    申请号：US13059164

    申请日：2009-08-14

    申请人： Michael R. Wood ,  Ian M. Bell ,  June J. Kim ,  Harold G. Selnick ,  Craig A. Stump

    发明人： Michael R. Wood ,  Ian M. Bell ,  June J. Kim ,  Harold G. Selnick ,  Craig A. Stump

    IPC分类号： C07D487/10 ,  A61K31/55 ,  A61P25/06

    CPC分类号： C07D471/20

    摘要： Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

    摘要翻译： 式（I）的化合物（其中变量R1A，R1B，R2，R3，R4，A和Z如本文所定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防CGRP 涉及受体，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

    Spirohydantoin aryl CGRP receptor antagonists
    10.
    发明授权
    Spirohydantoin aryl CGRP receptor antagonists 有权
    螺乙内酰脲芳基CGRP受体拮抗剂

    公开(公告)号：US08071770B2

    公开(公告)日：2011-12-06

    申请号：US12084917

    申请日：2006-11-14

    申请人： Ian M. Bell ,  Craig A. Stump ,  Cory R. Theberge ,  Michael R. Wood ,  C. Blair Zartman

    发明人： Ian M. Bell ,  Craig A. Stump ,  Cory R. Theberge ,  Michael R. Wood ,  C. Blair Zartman

    IPC分类号： C07D211/00 ,  C07D401/00

    CPC分类号： C07D487/10 ,  C07D471/10 ,  C07D519/00

    摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。