公开(公告)号：US20220175822A1

公开(公告)日：2022-06-09

申请号：US17436250

申请日：2020-02-27

申请人： Dow Global Technologies LLC

发明人： Caroline Woelfle-Gupta ,  Andrew Scott ,  Matthew LeBaron ,  Daniel Wilson ,  Susan L. Jordan ,  Robert L. Schmitt ,  Raja Settivari

IPC分类号： A61K31/765

摘要： Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I), where the treatment compound is a random copolymer, R1 is selected from hydrogen and a hydroxyl group, R2 is selected from hydrogen and a hydroxyl group, R1 is different than R2, and a sum of x and y is from 4 to 20,000.

公开(公告)号：US20220125830A1

公开(公告)日：2022-04-28

申请号：US17435110

申请日：2020-02-26

申请人： Dow Global Technologies LLC

发明人： Caroline Woelfle-Gupta ,  Andrew Scott ,  Matthew LeBaron ,  Daniel Wilson ,  Susan L. Jordan ,  Robert L. Schmitt ,  Raja Settivari

IPC分类号： A61K31/765

摘要： Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound formed by alkoxylation of an initiator using an oxide.

公开(公告)号：US20220054534A1

公开(公告)日：2022-02-24

申请号：US17435545

申请日：2020-02-26

申请人： Dow Global Technologies LLC

发明人： Caroline Woelfle-Gupta ,  Andrew Scott ,  Matthew LeBaron ,  Daniel Wilson ,  Susan L. Jordan ,  Robert L. Schmitt ,  Raja Settivari

IPC分类号： A61K31/765 ,  A61K31/795 ,  A61P35/00

摘要： Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I): where R1 is selected from hydrogen or an alkyl group having from 1 to about 16 carbon atoms; R2 is selected from a hydroxyl group, a tosylate group, an alkoxy group of the formula OR3 where R3 is selected from an alkyl group having from 1 to about 16 carbon atoms, or an ester group of the formula OCOR4, where R4 is an alkyl group having from 1 to about 16 carbon atoms, and n is from 4 to 46,000, with the proviso that when R1 is hydrogen and R2 is a hydroxy group the treatment compound has a number average molecular weight from 10,100 to 2,000,0000 g/mol.