公开(公告)号：US20250011885A1

公开(公告)日：2025-01-09

申请号：US18659841

申请日：2024-05-09

Applicant: Drexel University

Inventor： Brian Wigdahl ,  Michael R. Nonnemacher ,  William Dampier

IPC: C12Q1/70 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/689

Abstract: The invention relates to the compositions and methods for complete excision of HIV-1 proviral genomes including viral quasi-species (vQS) from an HIV-1-infected human. The invention includes a composition of guide RNAs (gRNAs) designed to specifically target the HIV-1 LTR region or any other region of the HIV-1 genome. The invention further includes a method for treating an HIV-1-infected human using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system and the compositions of the present invention.