公开(公告)号：US09228184B2

公开(公告)日：2016-01-05

申请号：US13842861

申请日：2013-03-15

Applicant: Dynavax Technologies Corporation

Inventor： Cristiana Guiducci ,  Karen L. Fearon ,  Franck Barrat

IPC: C12N15/117 ,  A61K31/7115 ,  A61K31/712 ,  C07H21/04 ,  C07H21/02 ,  A61K31/711 ,  A61K31/7125 ,  A61K31/713 ,  C12N15/11

CPC classification number: C12N15/11 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/331 ,  C12N2310/344

Abstract: Provided herein are human Toll-like receptor (TLR)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The TLR inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of TLR7, TLR8 and TLR9.

Abstract translation: 本文提供了人Toll样受体（TLR） - 抑制剂和用于具有自身免疫性疾病或炎症性疾病的个体的方法。 本公开的TLR抑制剂是包含TLR7，TLR8和TLR9中的一种或多种的抑制性基序的多核苷酸。

公开(公告)号：US09347064B2

公开(公告)日：2016-05-24

申请号：US14553857

申请日：2014-11-25

Applicant: Dynavax Technologies Corporation

Inventor： Franck Barrat ,  Robert L. Coffman ,  Cristiana Guiducci

IPC: A61K48/00 ,  C12N15/117 ,  A61K31/573 ,  A61K31/7125

CPC classification number: C12N15/117 ,  A61K31/573 ,  A61K31/7125 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/30 ,  C12N2320/31 ,  Y02A50/411 ,  C12N2310/3521

Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.

公开(公告)号：US09868955B2

公开(公告)日：2018-01-16

申请号：US14430876

申请日：2013-09-27

Applicant: Dynavax Technologies Corporation

Inventor： Cristiana Guiducci ,  Karen L. Fearon ,  Franck Barrat

IPC: C12N15/117 ,  A61K31/7125 ,  A61K31/712 ,  A61K31/7115 ,  A61K31/711 ,  A61K31/713

CPC classification number: C12N15/117 ,  C12N2310/17 ,  C12N2310/331 ,  C12N2310/344

Abstract: Provided herein are human Toll-like receptor (TLR)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The TLR inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of TLR7, TLR8 and TLR9.

公开(公告)号：US09476053B2

公开(公告)日：2016-10-25

申请号：US14613280

申请日：2015-02-03

Applicant: Dynavax Technologies Corporation

Inventor： Franck Barrat ,  Robert L. Coffman ,  Tracy Matray ,  Cristiana Guiducci

IPC: C12N15/117 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/7125 ,  A61K31/712 ,  A61K31/713 ,  A61K45/06

CPC classification number: C12N15/117 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/17 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/331 ,  C12N2310/3341 ,  C12N2310/336 ,  C12N2310/345 ,  C12N2310/3521

Abstract: The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.

公开(公告)号：US20150252363A1

公开(公告)日：2015-09-10

申请号：US14430876

申请日：2013-09-27

Applicant: DYNAVAX TECHNOLOGIES CORPORATION

Inventor： Cristiana Guiducci ,  Karen L. Fearon ,  Franck Barrat

IPC: C12N15/11

CPC classification number: C12N15/117 ,  C12N2310/17 ,  C12N2310/331 ,  C12N2310/344

Abstract: Provided herein are human Toll-like receptor (TLR)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The TLR inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of TLR7, TLR8 and TLR9.

Abstract translation: 本文提供了人Toll样受体（TLR） - 抑制剂和用于具有自身免疫性疾病或炎症性疾病的个体的方法。 本公开的TLR抑制剂是包含TLR7，TLR8和TLR9中的一种或多种的抑制性基序的多核苷酸。