公开(公告)号：US10322192B2

公开(公告)日：2019-06-18

申请号：US15892921

申请日：2018-02-09

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Earl F. Albone ,  Xin Cheng ,  Daniel W. Custar ,  Keiji Furuuchi ,  Jing Li ,  Utpal Majumder ,  Toshimitsu Uenaka

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  A61K31/357

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

公开(公告)号：US20180193478A1

公开(公告)日：2018-07-12

申请号：US15892921

申请日：2018-02-09

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Earl F. Albone ,  Xin Cheng ,  Daniel W. Custar ,  Keiji Furuuchi ,  Jing Li ,  Utpal Majumder ,  Toshimitsu Uenaka

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/32 ,  A61K31/357

CPC classification number: A61K47/6803 ,  A61K31/357 ,  A61K47/6849 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/14 ,  C07K2317/40 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

公开(公告)号：US10548986B2

公开(公告)日：2020-02-04

申请号：US15448497

申请日：2017-03-02

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Earl F. Albone ,  Xin Cheng ,  Daniel W. Custar ,  Keiji Furuuchi ,  Jing Li ,  Utpal Majumder ,  Toshimitsu Uenaka

IPC: A61K47/68 ,  C07K16/30 ,  A61K31/357 ,  C07K16/28 ,  C07K16/32

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

公开(公告)号：US20230398228A1

公开(公告)日：2023-12-14

申请号：US18062996

申请日：2022-12-07

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Earl F. Albone ,  Xin Cheng ,  Daniel W. Custar ,  Keiji Furuuchi ,  Jing Li ,  Utpal Majumder ,  Toshimitsu Uenaka

IPC: A61K47/68 ,  C07K16/30 ,  A61K31/357 ,  C07K16/28 ,  C07K16/32

CPC classification number: A61K47/6803 ,  C07K16/30 ,  A61K47/6889 ,  A61K47/6849 ,  A61K31/357 ,  C07K16/28 ,  C07K16/32 ,  C07K2317/14 ,  C07K2317/40 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

公开(公告)号：US11572414B2

公开(公告)日：2023-02-07

申请号：US17091819

申请日：2020-11-06

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Earl F. Albone ,  Jared Spidel

IPC: A61P35/00 ,  C07K16/30 ,  A61K47/68 ,  A61K47/60 ,  A61K31/357 ,  G01N33/574 ,  A61K39/00

Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates such as those comprising eribulin) thereof that bind to mesothelin are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the compositions provided herein.

公开(公告)号：US20200297860A1

公开(公告)日：2020-09-24

申请号：US16702720

申请日：2019-12-04

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Earl F. Albone ,  Xin Cheng ,  Daniel W. Custar ,  Keiji Furuuchi ,  Jing Li ,  Utpal Majumder ,  Toshimitsu Uenaka

IPC: A61K47/68 ,  C07K16/30 ,  A61K31/357 ,  C07K16/28 ,  C07K16/32

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.