公开(公告)号：US20230338522A1

公开(公告)日：2023-10-26

申请号：US18028039

申请日：2021-10-28

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yosuke WATANABE

IPC: A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/02 ,  A61K47/26 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K47/183 ,  A61K47/22 ,  A61K47/02 ,  A61K47/26 ,  C07K16/28

Abstract: [Problem] The purpose of the present disclosure is to provide a highly concentrated preparation of an anti-fractalkine (FKN) antibody, the preparation having viscosity that facilitates handling. [Solution] Provided is a pharmaceutical composition containing anti-FKN antibody at a concentration of 200 mg/mL. This pharmaceutical composition is characterized by containing 200 mg/mL of anti-FKN antibody and 100 to 400 mM of a basic amino acid wherein the basic amino acid comprises at least one amino acid selected from arginine, histidine, lysine, and ornithine.