公开(公告)号：US20220251171A1

公开(公告)日：2022-08-11

申请号：US17617504

申请日：2020-06-25

Applicant: EISAI R&D MANAGEMENT CO., LTD. ,  BioArctic AB

Inventor： Hiroaki Hagiwara ,  Kanta Horie ,  Kunihiko Kanatsu ,  Yasuharu Ishihara ,  Yasuaki Goto ,  Toru Oki ,  Masafumi Tsuboi ,  Charlotte Sahlin ,  Maria Eriksson ,  Christer Möller

IPC: C07K14/775 ,  G01N33/50 ,  G01N33/92 ,  A61P25/28

Abstract: The present invention relates to novel fragments of apolipoprotein E (ApoE). These ApoE fragments have a variety of uses including as components of vaccine compositions, particularly vaccines for the prevention or treatment of neurological disorders such as Alzheimer's disease. The ApoE fragments may also be used in screening methods and methods of detection.

公开(公告)号：US20220242939A1

公开(公告)日：2022-08-04

申请号：US17617469

申请日：2020-06-25

Applicant: BioArctic AB

Inventor： Charlotte Sahlin ,  Johanna Fälting ,  Christer Möller

IPC: C07K16/18 ,  G01N33/68 ,  A61P25/28

Abstract: The disclosure relates to an antibody or antigen binding portion thereof, which binds to a neo-epitope of a C-terminal fragment of apolipoprotein E, to methods of producing such an antibody or antigen binding portion thereof, and to therapeutic and diagnostic uses thereof.