公开(公告)号：US10105447B2

公开(公告)日：2018-10-23

申请号：US14765931

申请日：2014-03-12

申请人： ELANCO US INC. ,  Ambrx, Inc.

发明人： Michael Bledsoe ,  Peter Connor Canning ,  Michael Deguzman ,  Nick Knudsen ,  Ianina Valenta

IPC分类号： A61K38/22 ,  A61K47/48 ,  C07K14/575 ,  A61K47/60

摘要： Modified canine leptin polypeptides and formulations and uses thereof, are provided including polyethylene glycol (PEG) modified canine leptin polypeptides, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide, and related compositions and methods useful in treating companion animal obesity and other leptin-related disorders.

公开(公告)号：US10960080B2

公开(公告)日：2021-03-30

申请号：US16311540

申请日：2017-06-16

申请人： ELANCO US INC. ,  AMBRX, INC.

发明人： Peter Connor Canning ,  Nickolas Knudsen ,  Lillian Skidmore

IPC分类号： A61K47/60 ,  C07K14/56 ,  A61P31/14 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K38/00

摘要： Disclosed herein are porcine interferon alpha variants (pIFN-α) comprising a synthetic amino acid at select locations in pIFN-α and a one or two amino acid insertion in the N-terminus after removal of the signal peptide. The pIFN-α variants can further be pegylated. Methods of making and administering these compounds to treat virus infections in pigs and formulations comprising the variants are also provided.

公开(公告)号：US11578111B2

公开(公告)日：2023-02-14

申请号：US16754357

申请日：2018-10-10

申请人： Elanco US Inc. ,  Ambrx, Inc.

发明人： Peter Connor Canning ,  Nickolas Knudsen ,  Md Harunur Rashid

IPC分类号： C07K14/535 ,  A61K47/60 ,  A61P37/04 ,  A61P31/04 ,  A61K38/19

摘要： The present invention relates to variants of porcine granulocyte colony stimulating factor (pG-CSF). The pG-CSF variants are useful in treating preventing or reducing the incidence of bacterial infections in swine. Methods of treating swine are disclosed.