公开(公告)号：US20200094051A1

公开(公告)日：2020-03-26

申请号：US16576472

申请日：2019-09-19

申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE ,  KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES

发明人： Hyung Ju PARK ,  Dae-Sik LEE ,  Jae-Sung KIM ,  Yi Na YOON

IPC分类号： A61N1/36 ,  A61N1/378 ,  A61N1/08

摘要： Provided is a cancer treating device including a signal generator, a temperature sensor electrically connected to the signal generator, and a pair of electrodes which receive an AC voltage from the signal generator, wherein the signal generator is configured to generate an electric field between the electrodes so as to change orientations of ferroelectric particles inside a cancer cell, the temperature sensor measures a temperature around the cancer cell, and the signal generator may be configured to change the intensity of the electric field on the basis of the measured temperature.

公开(公告)号：US20210379022A1

公开(公告)日：2021-12-09

申请号：US17285464

申请日：2019-09-03

申请人： KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES

发明人： Jae Sung KIM ,  Ah Young KIM ,  Sang Gu HWANG ,  Jie Young SONG ,  Yi Na YOON

IPC分类号： A61K31/4184 ,  A61P35/00 ,  A23L33/10

摘要： The present invention relates to a pharmaceutical composition for preventing or treating cancer, a radiosensitizer composition for treating cancer, and a health functional food for preventing or improving cancer, which comprise N-1H-benzimidazol-2-yl-3-(1H-pyrrol-1-yl) benzamide, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition comprising N-1H-benzimidazol-2-yl-3-(1H-pyrrol-1-yl) benzamide or a derivative thereof as an active ingredient according to the present invention arrests the mitosis of cancer cells to prevent proliferation and at the same time, to exhibit low toxicity in normal cell lines and induce apoptosis only in cancer cell lines, so it can be used as an effective anticancer agent. In addition, the N-1H-benzimidazol-2-yl-3-(1H-pyrrol-1-yl) benzamide of the present invention can increase the sensitivity of the treated cancer cells to radiation, so it can be used as a radiosensitizer composition for cancer treatment.