公开(公告)号：US20150366983A1

公开(公告)日：2015-12-24

申请号：US14765931

申请日：2014-03-12

申请人： ELI LILLY & COMPANY ,  AMBRX, INC.

发明人： Michael BLEDSOE ,  Peter Connor CANNING ,  Michael DEGUZMAN ,  Nick KNUDSEN ,  Ianina VALENTA

IPC分类号： A61K47/48 ,  A61K38/22

CPC分类号： A61K38/2264 ,  A61K47/60 ,  C07K14/5759

摘要： Modified canine leptin polypeptides and formulations and uses thereof, are provided including polyethylene glycol (PEG) modified canine leptin polypeptides, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide, and related compositions and methods useful in treating companion animal obesity and other leptin-related disorders.

摘要翻译： 提供修饰的犬瘦素多肽及其制剂及其用途，包括聚乙二醇（PEG）修饰的犬瘦素多肽，其中PEG部分共价连接到多肽的对 - 乙酰基 - 苯丙氨酸（pAF）残基，以及相关组合物和方法 可用于治疗伴侣动物肥胖症和其他瘦素相关疾病。

公开(公告)号：US20190201491A1

公开(公告)日：2019-07-04

申请号：US16325345

申请日：2017-08-18

申请人： ELANCO US INC. ,  AMBRX, INC.

发明人： Peter Connor CANNING ,  Shailaja SRINAGESH ,  Anthony MANIBUSAN ,  Jason PINKSTAFF ,  Nickolas KNUDSEN

IPC分类号： A61K38/18 ,  A61P3/00 ,  C07K14/50 ,  A61K47/10

CPC分类号： A61K38/1825 ,  A61K38/00 ,  A61K38/18 ,  A61K47/10 ,  A61P3/00 ,  C07K14/503

摘要： The present application discloses PEG modified variants of a bFGF-21 polypeptide, compositions containing a bFGF-21 polypeptide variant, and methods useful in treating and/or preventing ketosis that administer the variant or a composition containing said bFGF-21 variant.

公开(公告)号：US20230340051A1

公开(公告)日：2023-10-26

申请号：US18102933

申请日：2023-01-30

申请人： Elanco US Inc. ,  Ambrx, Inc.

发明人： Peter Connor CANNING ,  Nickolas KNUDSEN ,  Md Harunur RASHID

IPC分类号： C07K14/535 ,  A61K47/60 ,  A61P37/04 ,  A61P31/04 ,  A61K38/19

CPC分类号： C07K14/535 ,  A61K47/60 ,  A61P37/04 ,  A61P31/04 ,  A61K38/193

摘要： The present invention relates to variants of porcine granulocyte colony stimulating factor (pG-CSF). The pG-CSF variants are useful in treating preventing or reducing the incidence of bacterial infections in swine. Methods of treating swine are disclosed.

公开(公告)号：US20210177980A1

公开(公告)日：2021-06-17

申请号：US17186642

申请日：2021-02-26

申请人： ELANCO US INC. ,  AMBRX, INC.

发明人： Peter Connor CANNING ,  Nickolas KNUDSEN ,  Lillian SKIDMORE

IPC分类号： A61K47/60 ,  C07K14/56 ,  A61P31/14 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12

摘要： Disclosed herein are porcine interferon alpha variants (pINF-α) comprising a synthetic amino acid at select locations in pINF-α and a one or two amino acid insertion in the N-terminus after removal of the signal peptide. The pINF-α variants can further be pegylated. Methods of making and administering these compounds to treat virus infections in pigs and formulations comprising the variants are also provided.

公开(公告)号：US20210054039A1

公开(公告)日：2021-02-25

申请号：US16754357

申请日：2018-10-10

申请人： Elanco US Inc. ,  Ambrx, Inc.

发明人： Peter Connor CANNING ,  Nickolas KNUDSEN ,  Md Harunur RASHID

IPC分类号： C07K14/535 ,  A61K38/19 ,  A61K47/60 ,  A61P37/04 ,  A61P31/04

摘要： The present invention relates to variants of porcine granulocyte colony stimulating factor (pG-CSF). The pG-CSF variants are useful in treating preventing or reducing the incidence of bacterial infections in swine. Methods of treating swine are disclosed.

公开(公告)号：US20190192673A1

公开(公告)日：2019-06-27

申请号：US16311540

申请日：2017-06-16

申请人： ELANCO US INC. ,  AMBRX, INC.

发明人： Peter Connor CANNING ,  Nickolas KNUDSEN ,  Lillian SKIDMORE

IPC分类号： A61K47/60 ,  C07K14/56 ,  A61K47/12 ,  A61K47/02 ,  A61K47/10 ,  A61K9/00 ,  A61P31/14

CPC分类号： A61K47/60 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61P31/14 ,  C07K14/56

摘要： Disclosed herein are porcine interferon alpha variants (pINF-α) comprising a synthetic amino acid at select locations in pINF-α and a one or two amino acid insertion in the N-terminus after removal of the signal peptide. The pINF-α variants can further be pegylated. Methods of making and administering these compounds to treat virus infections in pigs and formulations comprising the variants are also provided.