公开(公告)号：US11192864B2

公开(公告)日：2021-12-07

申请号：US16962287

申请日：2019-01-11

申请人： ENZYCHEM LIFESCIENCES CORPORATION

发明人： Jae Yong Lee ,  Jong Soo Lee ,  Byung Kyu Kang ,  Byuong Woo Lee ,  Sang Oh Lee ,  Dae Myoung Yun ,  Jae Hun Bang ,  Ki Young Sohn

IPC分类号： C07D257/02 ,  A61K49/10

摘要： Disclosed is a method for producing calcobutrol used as an MRI contrast agent. The method comprises the steps of: obtaining butrol represented by chemical formula 2 in the specification by reacting a gadobutrol represented by chemical formula 1 in the specification and a decomplexing agent; and obtaining a calcobutrol represented by chemical Formula 3 in the specification by reacting butrol with calcium ions.

公开(公告)号：US11091449B2

公开(公告)日：2021-08-17

申请号：US16642108

申请日：2018-08-29

申请人： ENZYCHEM LIFESCIENCES CORPORATION

发明人： Jae Young Lee ,  Jong Soo Lee ,  Byung Kyu Kang ,  Sang Oh Lee ,  Byouong Woo Lee ,  Dae Myoung Yun ,  Jae Hun Bang ,  Choi Kyung Seok

IPC分类号： A61K49/10 ,  C07D257/02 ,  C07F5/00

摘要： Disclosed are: an intermediate capable of high-purity synthesis of gadobutrol which can be used as an MRI contrast agent; and a gadobutrol production method using same. The gadobutrol intermediate is represented by Chemical Formula 2 in the specification.

公开(公告)号：US11319294B2

公开(公告)日：2022-05-03

申请号：US17193129

申请日：2021-03-05

申请人： ENZYCHEM LIFESCIENCES CORPORATION

发明人： Jong Soo Lee ,  Dae Myoung Yun ,  Byuong Woo Lee

IPC分类号： C07D257/02

摘要： It is disclosed a method for preparing calteridol used as MRI contrast agents. It provides a method for preparing calteridol comprising: obtaining teridol represented by the following Formula 2 by reacting gadoteridol represented by the following Formula 1 with decomplexing agent; and obtaining calteridol represented by the following Formula 3 by reacting calcium ion with teridol represented by following Formula 2.