公开(公告)号：US20170362217A1

公开(公告)日：2017-12-21

申请号：US15510588

申请日：2015-09-09

Applicant: EPIZYME, INC.

Inventor： Lorna Helen MITCHELL ,  Andrew Simon BELL ,  Richard CHESWORTH ,  Megan Alene Cloonan FOLEY ,  Kevin Wayne KUNTZ ,  James Edward John MILLS ,  Michael John MUNCHHOF

IPC: C07D451/04 ,  C07D487/08 ,  C07D413/14 ,  C07D519/00 ,  C07D413/12

CPC classification number: C07D451/04 ,  A61P35/00 ,  C07D413/12 ,  C07D413/14 ,  C07D487/08 ,  C07D519/00

Abstract: The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.