公开(公告)号：US20230075198A1

公开(公告)日：2023-03-09

申请号：US17268151

申请日：2019-08-14

Applicant: EPIZYME, INC.

Inventor： John LAMPE ,  John CAMPBELL ,  Kenneth DUNCAN ,  Megan Alene Cloonan FOLEY ,  Darren Martin HARVEY ,  Michael John MUNCHHOF ,  Michael THOMENIUS ,  Lawrence Alan REITER

IPC: C07D403/12 ,  C07D487/04 ,  C07D401/12 ,  C07D471/10 ,  C07D471/04 ,  C07D403/14 ,  C07D413/12 ,  C07D209/08 ,  C07D413/14 ,  C07D487/08 ,  C07D471/08 ,  C07D491/107 ,  C07D405/12 ,  C07D417/12 ,  C07D409/12 ,  C07D498/10 ,  C07D487/10 ,  C07D513/10 ,  C07D401/14 ,  C07D491/08 ,  C07D417/14 ,  C07D498/08 ,  A61P35/00

Abstract: The present disclosure provides substituted indole compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.