公开(公告)号：US20230133671A1

公开(公告)日：2023-05-04

申请号：US17904570

申请日：2021-02-19

Applicant: EPIZYME, INC.

Inventor： Maria Alejandra RAIMONDI ,  Jennifer Anne TOTMAN ,  Vinny MOTWANI ,  Katherine Louise COSMOPOULOS ,  John LAMPE

IPC: A61K31/496 ,  A61K31/407 ,  A61K45/06

Abstract: The present disclosure provides SETD2 protein inhibitors, and methods, compositions, and kits for treating diseases, disorders, or conditions in a subject with a SETD2 protein inhibitor and, optionally, a second therapeutic agent, wherein the second therapeutic agent comprises one or more glucocorticoid receptor agonists, one or more immunomodulatory drugs, one or more proteasome inhibitors, one or more Bcl-2 inhibitors, one or more pleiotropic pathway modulators, one or more XPO1 inhibitors, one or more histone deacetylase inhibitors, or one or more EZH2 inhibitors, or a combination thereof.

公开(公告)号：US20240299352A1

公开(公告)日：2024-09-12

申请号：US18568368

申请日：2022-06-08

Applicant: Epizyme, Inc.

Inventor： Maria Alejandra RAIMONDI ,  Jenniffer Anne TOTMAN ,  Vinny MOTWANI ,  Katherine Louise COSMOPOULOS ,  Dorothy BRACH ,  Daniel T. DRANSFIELD

IPC: A61K31/404 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure provides SETD2 protein inhibitors, and methods, uses, compositions, and kits for treating diseases, disorders, or conditions in a subject with a SETD2 protein inhibitor and a Second Therapeutic Agent, wherein the Second Therapeutic Agent comprises one or more BTK inhibitors, one or more anti-CD20 monoclonal antibodies, one or more alkylating agents, one or more topoisomerase II inhibitors, one or more vinca alkaloids, one or more platinum-based drugs, one or more nucleoside anticancer agents, one or more PI3K inhibitors, one or more CDK4/6 inhibitors, one or more CARM1 inhibitors, one or more inhibitors of enzymes of DNA damage repair, one or more SYK inhibitors, or one or more MEK inhibitors, or a combination thereof.