公开(公告)号：US20200046729A1

公开(公告)日：2020-02-13

申请号：US16573611

申请日：2019-09-17

申请人： ESTETRA SPRL

发明人： Maud JOST ,  Glwadys RAUSIN

IPC分类号： A61K31/565 ,  A61K31/585 ,  A61P15/18

摘要： Described are combined oral contraceptive compositions with reduced cardiovascular effects and methods using them. In some embodiments, the methods relate to contraceptive methods or methods for treating dysmenorrhea with reduced cardiovascular effects, such as reduced venous thromboembolism (VTE) risk. The methods comprise administering to a female subject an effective amount of an estetrol component and a progestogenic component. The methods enjoy a favourable profile for thromboembolism compared to currently available methods which employs contraceptives from the so-called second, third or fourth generation.

公开(公告)号：US20190167700A1

公开(公告)日：2019-06-06

申请号：US16323110

申请日：2017-08-07

申请人： ESTETRA SPRL

发明人： Maud JOST ,  Glwadys RAUSIN

IPC分类号： A61K31/585 ,  A61P15/00 ,  A61K31/566

摘要： The present invention relates to a method for the management of dysmenorrhea involving administration of an estrogenic component which is preferably selected from the group consisting of estetrol and estetrol-like compounds. Estetrol-like compounds have been surprisingly found to be capable of mitigating dysmenorrhea, either when used alone or in combination with progestogenic components, and this to an extent surpassing the effect obtained with other compositions and with a favourable side-effect profile compared to currently available methods.