-
公开(公告)号：US20200172925A1
公开(公告)日：2020-06-04
申请号：US16317747
申请日：2017-07-14
申请人： ETUBICS CORPORATION
摘要： Compositions of a recombinant adenovirus based vector vaccine containing one or more alphavirus antigen genes are disclosed herein. Methods for constructing and producing such vaccines and methods of using these vaccines to generate broad based immune responses against alphaviruses are also described. Compositions described herein allow for vaccinations in individuals with preexisting immunity to adenovirus.
-
公开(公告)号：US20200171140A1
公开(公告)日：2020-06-04
申请号：US16317739
申请日：2017-07-14
申请人： ETUBICS CORPORATION
摘要： Compositions of a recombinant adenovirus based vector vaccine containing one or more flavivirus antigen genes are disclosed herein. Methods for constructing and producing such vaccines and methods of using these vaccines to generate immune responses against flaviviruses are also described. Compositions described herein allow for vaccinations in subjects with preexisting immunity to adenovirus.
-
3.发明申请公开(公告)号：US20190125852A1
公开(公告)日：2019-05-02
申请号：US16306097
申请日：2017-06-02
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for constructing and producing recombinant adenovirus-based vector vaccines are provided. In particular aspects, there are be provided compositions and methods involving adenovirus vectors comprising genes for target antigens, such as pro state-specific antigen (PSA), pro state-specific membrane antigen (PSMA), MUC1, CEA, and/or Brachyury, and costimulatory molecules for use in treatment methods that generate highly reactive anti-tumor immune responses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus.
-
公开(公告)号：US20200282032A1
公开(公告)日：2020-09-10
申请号：US16304740
申请日：2017-05-26
摘要： In certain embodiments, methods and compositions are provided for generating immune responses against tumor neo-antigens or neo-epitopes. In particular embodiments there may be provided methods for constructing and producing recombinant adenovirus-based vector vaccines containing nucleic acid sequences encoding tumor neo-antigens and neo-epitopes that allow for vaccinations in individuals with preexisting immunity to adenovirus. In additional embodiments, methods and compositions are provided for the treatment of cancer using immunotherapy based on recombinant adenovirus-based vectors combined with engineered natural killer cells. In some embodiments, the methods and compositions further comprises a nucleic acid encoding for an immunological fusion partner.
-
5.发明申请公开(公告)号：US20190134195A1
公开(公告)日：2019-05-09
申请号：US16306076
申请日：2017-06-02
申请人： ETUBICS CORPORATION
IPC分类号： A61K39/395 , A61P31/20 , A61P35/00 , A61K39/235 , A61K47/00 , C12N15/113 , A61K39/39
摘要： Methods and compositions for constructing and producing recombinant adenovirus-based vector vaccines are provided. In particular aspects, there are be provided compositions and methods involving adenovirus vectors comprising genes for target antigens, such as novel antigens of HPV E6 and/or HPV E7 for use in treatment methods that generate highly reactive anti-HPV and anti-tumor immune responses in subjects with preexisting immunity to adenovirus.
-
公开(公告)号：US20210138056A1
公开(公告)日：2021-05-13
申请号：US17148324
申请日：2021-01-13
摘要： In certain embodiments, methods and compositions are provided for generating immune responses against tumor neo-antigens or neo-epitopes. In particular embodiments there may be provided methods for constructing and producing recombinant adenovirus-based vector vaccines containing nucleic acid sequences encoding tumor neo-antigens and neo-epitopes that allow for vaccinations in individuals with preexisting immunity to adenovirus. In additional embodiments, methods and compositions are provided for the treatment of cancer using immunotherapy based on recombinant adenovirus-based vectors combined with engineered natural killer cells. In some embodiments, the methods and compositions further comprises a nucleic acid encoding for an immunological fusion partner.
-
公开(公告)号：US20200155662A1
公开(公告)日：2020-05-21
申请号：US16614909
申请日：2018-05-25
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.
-
公开(公告)号：US20180344832A1
公开(公告)日：2018-12-06
申请号：US15564413
申请日：2016-04-20
申请人： ETUBICS CORPORATION
IPC分类号： A61K39/00 , A61K39/395 , A61K31/519 , A61K31/513 , A61K31/282 , A61K38/17 , C12N15/86
CPC分类号： C07K16/3007 , A61K39/0011 , A61K39/12 , A61K39/292 , A61K2039/505 , A61K2039/5256 , A61K2039/545 , A61K2039/572 , A61K2039/575 , C07K16/081 , C07K16/2818 , C07K2317/76 , C12N2710/10034 , C12N2710/10041 , C12N2710/20034 , Y02A50/464
摘要： Methods and compositions for generating immune responses using adenovirus vectors that allow multiple vaccinations or in combination with other therapy and vaccinations in individuals with preexisting immunity to adenovirus are provided.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.021 秒)
