公开(公告)号：US20180009892A1

公开(公告)日：2018-01-11

申请号：US15654514

申请日：2017-07-19

申请人： EUREKA THERAPEUTICS, INC.

发明人： CHENG LIU ,  YIYANG XU ,  HONG LIU ,  SU YAN ,  JINGYI XIANG ,  PEI WANG

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/2803 ,  A61K38/05 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6881 ,  A61K51/1027 ,  A61K51/1042 ,  A61K51/1096 ,  A61K2039/505 ,  A61P35/00 ,  A61P35/02 ,  C07K16/005 ,  C07K16/2809 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/57492 ,  G01N2333/912

摘要： The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.