公开(公告)号：US20170158761A1

公开(公告)日：2017-06-08

申请号：US15382277

申请日：2016-12-16

Applicant: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

Inventor： Kyunglim Lee ,  Dong Hae Shin ,  Mi-Sun Kim ,  Mi Young Kim ,  Jeehye Maeng ,  Hee-Won Lee

IPC: C07K16/24 ,  A61K9/48 ,  A61K9/20 ,  A61K39/395 ,  A61K9/14

Abstract: The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structual region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, bronchitis, chronic obstructive pulmonary disease, bronchiectasis, rhinitis, atopic dermatitis, hives (urticaria), hay fever, conjunctivitis, and anaphylaxis; inflammatory diseases such as bronchitis, pneumonia, arthritis, nephritis, psoriasis, dermatitis, Crohn's disease, enteritis, gingivitis, arteriosclerosis, coronary arteritis, hepatitis, Behcet's disease, bladder cancer, prostatitis, pyelonephritis, glomerulonephritis, osteomyelitis, thyroiditis, uveitis, abdominal cavity inflammation, meningitis, pulmonary fibrosis and rheumatoid arthritis; and malaria, and a method for screening for the HRF-related diseases.

公开(公告)号：US10703812B2

公开(公告)日：2020-07-07

申请号：US15382277

申请日：2016-12-16

Applicant: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION

Inventor： Kyunglim Lee ,  Dong Hae Shin ,  Mi-Sun Kim ,  Mi Young Kim ,  Jeehye Maeng ,  Hee-Won Lee

IPC: A61K38/16 ,  C07K16/24 ,  A61K39/395 ,  C07K14/47 ,  A61K38/19 ,  A61P27/14 ,  C07K14/52 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K39/00

Abstract: The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structural region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, bronchitis, chronic obstructive pulmonary disease, bronchiectasis, rhinitis, atopic dermatitis, hives (urticaria), hay fever, conjunctivitis, and anaphylaxis; inflammatory diseases such as bronchitis, pneumonia, arthritis, nephritis, psoriasis, dermatitis, Crohn's disease, enteritis, gingivitis, arteriosclerosis, coronary arteritis, hepatitis, Behcet's disease, bladder cancer, prostatitis, pyelonephritis, glomerulonephritis, osteomyelitis, thyroiditis, uveitis, abdominal cavity inflammation, meningitis, pulmonary fibrosis and rheumatoid arthritis; and malaria, and a method for screening for the HRF-related diseases.