公开(公告)号：US20220287970A1

公开(公告)日：2022-09-15

申请号：US17636319

申请日：2021-05-28

申请人： EYEGENE INC

发明人： Yang Je CHO ,  Na Gyong LEE ,  Kwangsung KIM ,  Shin Ae PARK ,  Sunyoung AHN

IPC分类号： A61K9/127 ,  A61P7/04 ,  A61K31/704

摘要： A cationic liposome having the effect of inhibition of red blood cell hemolysis induced by saponin is disclosed. More particularly, a composition for inhibiting red blood cell hemolysis by saponin comprising a cationic liposome containing an unsaturated lipid, a composition for immunity enhancement and a composition for drug delivery comprising the composition for inhibiting red blood cell hemolysis by saponin, and a drug delivery carrier and a drug-carrier complex comprising a cationic liposome containing an unsaturated lipid are disclosed.
Saponin exhibits a wide range of pharmacological and biological activities, such as anti-inflammatory activity, etc., including strong and effective immunological activity, and thus is effectively used medically and pharmaceutically, but has a disadvantage of causing hemolysis to red blood cells. Although saponin is generally used along with cholesterol, etc. to inhibit the hemolysis of saponin, it is confirmed herein that red blood cell hemolysis by saponin can be inhibited using a cationic liposome, which is more effective and economical in inhibiting the hemolysis of saponin. Therefore, saponin can be more usefully applied to the manufacture of immunity enhancers, drug delivery carriers, etc.