公开(公告)号：US20240287017A1

公开(公告)日：2024-08-29

申请号：US18569830

申请日：2022-06-14

Applicant: East China University of Science and Technology

Inventor： Jinghong ZHOU ,  Xiaofeng XU ,  Yueqiang CAO ,  Wei LI

IPC: C07D319/12 ,  C07C67/02

CPC classification number: C07D319/12 ,  C07C67/02

Abstract: This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas:




wherein, the ROH represents a straight/branched chain alcohol, acid or ester containing 18-30 carbons and at least one hydroxyl group. The method for glycolide synthesis disclosed in the present invention manages to maintain a low viscosity within the reaction system by introducing a high-boiling alcohol into the reaction system to form a larger alkoxy glycolate exhibiting a significantly lower molecular weight compared to the typical glycolic acid oligomers utilized in the conventional process. Thus the challenges of coking and inefficient heat transfer encountered in traditional glycolide synthesis routes are effectively addressed.