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8 条记录 (耗时 0.023 秒)

    (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents
    2.
    发明授权
    (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents 失效
    （5,6-二氯-3-氧代-2,3,9,9a-四氢芴-7-基） - 链烷酸和带有新的功能性9a取代基的烷酰亚胺

    公开(公告)号：US4731471A

    公开(公告)日：1988-03-15

    申请号：US926170

    申请日：1986-11-03

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr. ,  Adolph M. Pietruszkiewicz

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr. ,  Adolph M. Pietruszkiewicz

    IPC分类号： C07C45/46 ,  C07C45/67 ,  C07C45/75 ,  C07C69/94

    CPC分类号： C07C45/67 ,  C07C45/46 ,  C07C45/75 ,  C07C2103/18

    摘要： The invention relates to novel [(5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)]alkanoic acids and alkanimidamides bearing novel functional 9a-substituents, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.

    摘要翻译： 本发明涉及新的[（5,6-二氯-3-氧代-2,3,9,9a-四氢芴-7-基）]链烷酸和具有新的功能性9a-取代基及其衍生物及其盐的链烷酰胺。 这些化合物可用于治疗和预防脑损伤以及头部创伤，中风（特别是缺血性），呼吸停止，心脏停搏，雷氏综合症，脑血栓形成，脑栓塞，艾滋病引起的神经系统问题， 脑出血，脑肿瘤，脑脊髓炎，脊髓损伤，脑积水，术后脑损伤创伤，脑部感染引起的水肿，各种脑震荡和颅内压升高。

    Substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy) alkanoic acids, their derivatives and their salts
    3.
    发明授权
    Substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy) alkanoic acids, their derivatives and their salts 失效
    取代的（2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基）链烷酸，其衍生物及其盐

    公开(公告)号：US4625047A

    公开(公告)日：1986-11-25

    申请号：US812669

    申请日：1985-12-23

    申请人： Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07C59/88 ,  C07C69/76

    CPC分类号： C07C59/88

    摘要： The invention relates to novel substituted [2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy]-alkanoic acids their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代的2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基] - 链烷酸及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    ((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides
    4.
    发明授权
    ((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides 失效
    （（5,6-二氯-3-氧代-9,9a-二取代-2,3,9,9a-四氢芴-7-基）氧基）链烷酸和烷酰胺

    公开(公告)号：US4797391A

    公开(公告)日：1989-01-10

    申请号：US150462

    申请日：1988-02-08

    申请人： Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz

    发明人： Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz

    IPC分类号： C07C49/755 ,  C07F9/24 ,  A61K31/645 ,  C07C129/12

    CPC分类号： C07C49/755 ,  C07F9/2466 ,  C07C2103/18

    摘要： The invention relates to novel [(5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydro-fluoren-7-yl)oxy]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.

    摘要翻译： 本发明涉及新的[（5,6-二氯-3-氧代-9,9a-二取代-2,3,9,9a-四氢 - 芴-7-基）氧]链烷酸和烷酰胺，其衍生物及其衍生物 盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，脑部感染引起的水肿，各种脑震荡和颅内压升高。

    Ester and amide substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy)alkanoic acids and their salts
    7.
    发明授权
    Ester and amide substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy)alkanoic acids and their salts 失效
    酯和酰胺取代的（2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基）链烷酸及其盐

    公开(公告)号：US4719310A

    公开(公告)日：1988-01-12

    申请号：US812671

    申请日：1985-12-23

    申请人： Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr.

    发明人： Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr.

    IPC分类号： C07C59/68 ,  C07C69/76

    CPC分类号： C07C59/68

    摘要： The invention relates to novel ester and amide substituted [2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy]alkanoic acids and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的酯和酰胺取代的[2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基]链烷酸及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    [(2-substituted 1,2-dihydro-1-oxo-1H-inden-5-yl)oxy]alkanesulfonic acids and salts thereof
    8.
    发明授权
    [(2-substituted 1,2-dihydro-1-oxo-1H-inden-5-yl)oxy]alkanesulfonic acids and salts thereof 失效
    [（2-取代的1,2-二氢-1-氧代-1H-茚-5-基）氧基]烷基磺酸及其盐

    公开(公告)号：US4771076A

    公开(公告)日：1988-09-13

    申请号：US56174

    申请日：1987-06-01

    申请人： Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz

    发明人： Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz

    IPC分类号： A61K31/12 ,  C07C309/09 ,  C07C143/24

    CPC分类号： C07C309/00

    摘要： This invention relates to novel [(2-substituted 1,2-dihydro-1-oxo-1H-inden-5-yl)oxy]alkanesulfonic acids and salts thereof. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions, and elevated intracranial pressure.

    摘要翻译： 本发明涉及新的[（2-取代的1,2-二氢-1-氧代-1H-茚-5-基）氧基]烷基磺酸及其盐。 这些化合物可用于治疗和预防脑损伤以及头部创伤，中风（特别是缺血性），呼吸停止，心脏停搏，雷氏综合症，脑血栓形成，脑栓塞，艾滋病引起的神经系统问题， 脑出血，脑肿瘤，脑脊髓炎，脊髓损伤，脑积水，术后脑损伤创伤，脑部感染引起的水肿，各种脑震荡和颅内压升高。