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1.发明授权Devices, systems and methods using magnetic force systems affecting the tongue or hyoid muscles in the upper airway 有权使用磁力系统的装置，系统和方法影响上呼吸道中的舌头或hy肌公开(公告)号：US08020560B2
公开(公告)日：2011-09-20
申请号：US11592637
申请日：2006-11-03
申请人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Octavian Iancea , Andrew W. Kramer , Brian K. McCollum , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
发明人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Octavian Iancea , Andrew W. Kramer , Brian K. McCollum , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Systems and methods are provided for resisting posterior movement of the tongue during sleep, thereby keeping an airway open. The systems and methods employ a first structure that can be placed either in or on a tongue within an oral cavity and/or in a region of hyoid muscle. The first structure includes a ferromagnetic material. The systems and methods employ a second structure that can be placed either in or on external tissue outside the oral cavity and/or in or on external tissue outside the oral cavity in a desired relationship with the first structure. The second structure includes a magnetic material that magnetically interacts with the ferromagnetic material by attracting the ferromagnetic material, thereby resisting posterior movement of the tongue.
摘要翻译： 提供了系统和方法，用于抵抗睡眠期间舌头的后运动，从而保持呼吸道畅通。 该系统和方法采用可以放置在口腔内和/或舌骨区域内或舌上的第一结构。 第一结构包括铁磁材料。 该系统和方法采用第二结构，该第二结构可以以与第一结构的期望的关系置于口腔外部和/或外部组织外部和/或外部组织中或外部组织中。 第二结构包括通过吸引铁磁材料与铁磁材料磁性相互作用的磁性材料，从而抵抗舌头的后部运动。
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2.发明授权公开(公告)号：US08327854B2
公开(公告)日：2012-12-11
申请号：US13269520
申请日：2011-10-07
申请人： Edward M. Gillis , Octavian Iancea
发明人： Edward M. Gillis , Octavian Iancea
IPC分类号： A61F5/56
摘要： A method of maintaining airway patency in an airway of a patient which includes the steps of implanting a device into tissue adjacent an airway, the device having a bioerodable material wound around a resiliently deformable body to temporarily maintain the deformable body in a stretched, deformed state, and permitting the bioerodable material of the device to bioerode to apply a force to maintain airway patency. The invention also provides devices for practicing the method.
摘要翻译： 一种在患者气道中保持气道通畅的方法，其包括将装置植入邻近气道的组织中的步骤，所述装置具有缠绕在弹性可变形体上的生物可蚀塑料，以暂时将变形体保持在拉伸变形状态 并且允许该装置的生物可蚀塑料进行生化代谢以施加力以维持气道通畅。 本发明还提供了用于实施该方法的装置。
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公开(公告)号：US20120024298A1
公开(公告)日：2012-02-02
申请号：US13269520
申请日：2011-10-07
申请人： Edward M. Gillis , Octavian Iancea
发明人： Edward M. Gillis , Octavian Iancea
IPC分类号： A61F5/56
摘要： A method of maintaining airway patency in an airway of a patient which includes the steps of implanting a device into tissue adjacent an airway, the device having a bioerodable material wound around a resiliently deformable body to temporarily maintain the deformable body in a stretched, deformed state, and permitting the bioerodable material of the device to bioerode to apply a force to maintain airway patency. The invention also provides devices for practicing the method.
摘要翻译： 一种在患者气道中保持气道通畅的方法，其包括将装置植入邻近气道的组织中的步骤，所述装置具有缠绕在弹性可变形体上的生物可蚀塑料，以暂时将变形体保持在拉伸变形状态 并且允许该装置的生物可蚀塑料进行生化代谢以施加力以维持气道通畅。 本发明还提供了用于实施该方法的装置。
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4.发明授权公开(公告)号：US08707960B2
公开(公告)日：2014-04-29
申请号：US12937564
申请日：2009-05-11
申请人： Edward M. Gillis , Octavian Iancea
发明人： Edward M. Gillis , Octavian Iancea
IPC分类号： A61F5/56
摘要： A method of maintaining airway patency in an airway of a patient. The method includes the steps of implanting a device into airway-forming tissue without affixing the device to the tissue and permitting a bioerodable portion of the device to bioerode to apply a force to the airway-forming tissue to maintain airway patency. The invention also provides devices for practicing the method.
摘要翻译： 维持患者气道通气通畅的方法。 该方法包括以下步骤：将装置植入气道形成组织中，而不将装置固定在组织上，并允许装置的生物可蚀染部分进行生物代谢反应，以对气道形成组织施加力以保持气道通畅。 本发明还提供了用于实施该方法的装置。
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公开(公告)号：US20130098374A1
公开(公告)日：2013-04-25
申请号：US13711537
申请日：2012-12-11
申请人： Edward M. Gillis , Octavian Iancea
发明人： Edward M. Gillis , Octavian Iancea
IPC分类号： A61F5/56
摘要： A method of maintaining airway patency in an airway of a patient which includes the steps of implanting a device into tissue adjacent an airway, the device having a bioerodable material wound around a resiliently deformable body to temporarily maintain the deformable body in a stretched, deformed state, and permitting the bioerodable material of the device to bioerode to apply a force to maintain airway patency. The invention also provides devices for practicing the method.
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公开(公告)号：US20110144421A1
公开(公告)日：2011-06-16
申请号：US12937564
申请日：2009-05-11
申请人： Edward M. Gillis , Octavian Iancea
发明人： Edward M. Gillis , Octavian Iancea
IPC分类号： A61F2/00
摘要： A method of maintaining airway patency in an airway of a patient. The method includes the steps of implanting a device into airway-forming tissue without affixing the device to the tissue and permitting a bioerodable portion of the device to bioerode to apply a force to the airway-forming tissue to maintain airway patency. The invention also provides devices for practicing the method.
摘要翻译： 维持患者气道通气通畅的方法。 该方法包括以下步骤：将装置植入气道形成组织中，而不将装置固定在组织上，并允许装置的生物可蚀染部分进行生物代谢反应，以对气道形成组织施加力以保持气道通畅。 本发明还提供了用于实施该方法的装置。
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公开(公告)号：US09463112B2
公开(公告)日：2016-10-11
申请号：US11592429
申请日：2006-11-03
申请人： Andres D. Tomas , Ryan P. Boucher , Edward M. Gillis , Scott A. McGill , Lionel M. Nelson , Joe Paraschac
发明人： Andres D. Tomas , Ryan P. Boucher , Edward M. Gillis , Scott A. McGill , Lionel M. Nelson , Joe Paraschac
IPC分类号： A61F5/56
摘要： A carrier is sized and configured for placement in or on a tissue region. The carrier includes at least one interior compartment. At least one ferromagnetic material is carried within the compartment. The compartment and the ferromagnetic material are mutually sized and configured to allow movement of the ferromagnetic material within the compartment in response to magnetic interaction with a magnetic material located outside the carrier. The magnetic interaction can include either a magnetic attracting force or a magnetic repelling force. The carrier can be used in association with a source of magnetism sized and configured for placement in or on a tissue region outside the carrier for magnetic interaction with the ferromagnetic material carried within the compartment, e.g., to stabilize the orientation of a tissue region within an airway.
摘要翻译： 载体的尺寸和构造适于放置在组织区域中或组织区域上。 载体包括至少一个内部隔室。 至少一个铁磁材料被携带在隔间内。 隔室和铁磁材料相互尺寸和构造成允许响应于位于载体外部的磁性材料的磁相互作用而使铁磁材料在隔间内移动。 磁相互作用可以包括磁吸引力或磁排斥力。 载体可以与尺寸和构造用于放置在载体外部的组织区域中或其上的磁性源结合使用，以与在隔室内承载的铁磁材料磁性相互作用，例如以稳定组织区域内的取向 气道。
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8.发明授权Devices, systems and methods using magnetic force systems affecting both the tongue and the soft palate/uvula in the upper airway 失效使用影响上呼吸道舌头和软腭/尿道的磁力系统的装置，系统和方法公开(公告)号：US08528564B2
公开(公告)日：2013-09-10
申请号：US11592562
申请日：2006-11-03
申请人： Joseph Paraschac , Ryan P. Boucher , Edward M. Gillis , Andrew W. Kramer , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
发明人： Joseph Paraschac , Ryan P. Boucher , Edward M. Gillis , Andrew W. Kramer , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
IPC分类号： A61F5/56
摘要： Systems and methods resist posterior movement of both the tongue and the soft palate/uvula during sleep, thereby keeping an airway open. The systems and methods employ first, second, and third structures. The first structure is sized and configured for placement in or on a tongue. The second structure is sized and configured for placement in or on a region of a soft palate or uvula. The third structure is sized and configured for placement in or on tissue in a desired relationship. anterior of the first and second structures. The first and second structures each includes a ferromagnetic material. The third structure includes a magnetic material that magnetically interacts with both the first and second ferromagnetic materials by attracting both the first and second ferromagnetic materials, thereby resisting posterior movement of both the tongue and the soft palate/uvula.
摘要翻译： 系统和方法可防止睡眠期间舌和软腭/尿囊的后移，从而保持呼吸道畅通。 系统和方法采用第一，第二和第三结构。 第一个结构的大小和配置用于放置在舌头上或舌头上。 第二结构的尺寸和构造用于放置在软腭或尿囊的区域中或上。 第三结构的尺寸和构造用于以期望的关系放置在组织中或组织上。 第一和第二结构的前面。 第一和第二结构各自包括铁磁材料。 第三结构包括磁性材料，其通过吸引第一和第二铁磁材料两者而与第一和第二铁磁材料两者磁性相互作用，从而抵抗舌和软腭/囊的后运动。
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9.发明授权公开(公告)号：US08167787B2
公开(公告)日：2012-05-01
申请号：US11969201
申请日：2008-01-03
申请人： Edward M. Gillis
发明人： Edward M. Gillis
IPC分类号： A61F2/00
摘要： The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable configuration. The gradual nature of the shape change generally stabilizes the device in the tissue, and supports tissue reforming into a stable configuration.
摘要翻译： 本发明涉及用于重组患有阻塞性睡眠呼吸暂停的受试者的气道周围的组织以便打开气道并减轻呼吸暂停事件的发生的装置和方法。 装置包括可弹性变形材料和生物可腐蚀材料的组合。 装置的可变形部分具有对应于一旦放置在气道中的装置的期望最终形状的优选形状。 然而，在制造移植就绪装置中，可变形部分被放置成变形的形状并且被生物可腐蚀的材料限制在该形状中。 植入后，随着约束生物可侵蚀材料侵蚀，装置逐渐呈现出优选的形状。 随着装置逐渐改变为优选的形状，它将组织改造成治疗期望的构型。 形状变化的逐渐性质通常使组织中的装置稳定，并支持组织重整成稳定的构型。
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公开(公告)号：US08047206B2
公开(公告)日：2011-11-01
申请号：US11404631
申请日：2006-04-14
IPC分类号： A61F13/00
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue. The magnetic structures include magnetic materials that are sized, configured, and arranged on at least one of the first and second magnetic structures, to maintain a substantially mutually repelling orientation between the first and second magnetic structures during a native range of movement of the tongue relative to the pharyngeal wall, i.e., during swallowing and/or drinking/and or speech.
摘要翻译： 磁性结构在舌头和后咽壁之间产生磁力，以稳定舌头的取向。 磁性结构包括磁性材料，其尺寸，构造和布置在第一和第二磁性结构中的至少一个上，以在舌形相对的自然运动范围内在第一和第二磁性结构之间保持基本相互排斥的取向 到咽壁，即在吞咽和/或饮酒和/或言语期间。
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