公开(公告)号：US07429564B2

公开(公告)日：2008-09-30

申请号：US10500822

申请日：2003-01-07

申请人： Ehud Arbit ,  Richat Abbas ,  Michael Goldberg ,  T. Cooper Woods ,  Steven Dinh ,  Vivien Wong

发明人： Ehud Arbit ,  Richat Abbas ,  Michael Goldberg ,  T. Cooper Woods ,  Steven Dinh ,  Vivien Wong

IPC分类号： A61K38/28

CPC分类号： A61K47/18 ,  A61K9/2013 ,  A61K9/4858 ,  A61K38/28 ,  A61K2300/00

摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.

摘要翻译： 用于口服给予患者用于治疗糖尿病的药物剂型，其包含胰岛素和促进胰岛素以治疗有效量转运至血液并导致与重复施用胰岛素相关的血管疾病的较低发生率的递送剂 被披露。 还公开了一种减轻与慢性给药胰岛素相关的疾病的不期望的发病率的方法，其中通过口服给予胰岛素患者以及促进从患者的胃肠道吸收胰岛素的合适的递送剂 治疗有效量，用于治疗糖尿病。