公开(公告)号：US20230051268A1

公开(公告)日：2023-02-16

申请号：US17757672

申请日：2020-12-18

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Andrew SATLIN ,  Margaret MOLINE ,  Ishani LANDRY

IPC: A61K31/506 ,  A61K9/00

Abstract: Disclosed are methods for treating insomnia, comprising administering orally a dosage form comprising Lemborexant or a pharmaceutically acceptable salt thereof to a patient in need thereof at a single daily dose ranging from 5 mg to 10 mg of lemborexant or an equivalent dose of a pharmaceutically acceptable salt thereof, provided that the maximum dose is 5 mg once per day of lemborexant or an equivalent dose of a pharmaceutically acceptable salt thereof when the patient has moderate hepatic impairment classified in Child-Pugh class B under Child-Pugh Classification.

公开(公告)号：US20200299411A9

公开(公告)日：2020-09-24

申请号：US16345012

申请日：2017-10-26

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Andrew SATLIN ,  Tatsuto FUKUSHIMA

IPC: C07K16/44 ,  A61K31/542 ,  A61P25/28

Abstract: Methods and combination therapies for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti-Aβ protofibril antibody (such as, for example, BAN2401) and N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.

公开(公告)号：US20190276560A1

公开(公告)日：2019-09-12

申请号：US16345012

申请日：2017-10-26

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Andrew SATLIN ,  Tatsuto FUKUSHIMA

IPC: C07K16/44 ,  A61K31/542 ,  A61P25/28

Abstract: Methods and combination therapies for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti-Aβ protofibril antibody (such as, for example, BAN2401) and N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.