公开(公告)号：US11707448B2

公开(公告)日：2023-07-25

申请号：US17528510

申请日：2021-11-17

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Xingfeng Bao ,  Diana Albu ,  Mary Woodall-Jappe

IPC: A61K31/415 ,  A61K31/7068 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K31/415 ,  A61K31/7068 ,  A61K39/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2300/00

Abstract: The present invention provides methods and compositions for treating cancer by administering an EP4 antagonist in combination with radiation therapy, antibody therapy and/or anti-metabolite chemotherapy.