公开(公告)号：US20170360797A1

公开(公告)日：2017-12-21

申请号：US15527375

申请日：2015-11-17

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Brett TRUITT ,  Yuta SUZUKI ,  Tsukasa MURASE ,  Futoshi SHIKATA

IPC: A61K31/5377 ,  A61K9/20 ,  A61K9/00 ,  A61K9/28

Abstract: The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).

公开(公告)号：US20230103250A1

公开(公告)日：2023-03-30

申请号：US17787752

申请日：2021-01-14

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Taichi ABE ,  Yusuke AYATA ,  Nobuya SUZUKI ,  Yurie AKIMOTO ,  Futoshi SHIKATA ,  Yasuhiro Zaima ,  Nobuo YOSHIDA

IPC: A61K31/506 ,  A61K9/20 ,  A61K9/16

Abstract: There is provided a pharmaceutical composition comprising lemborexant exhibiting a favorable dissolution profile by using a granular material having a 90% cumulative diameter (D90) of 64 μm or less as a lemborexant active pharmaceutical ingredient.

公开(公告)号：US20210060030A1

公开(公告)日：2021-03-04

申请号：US16998144

申请日：2020-08-20

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Heike KEILHACK ,  Brett TRUITT ,  Yuta SUZUKI ,  Tsukasa MURASE ,  Futoshi SHIKATA

IPC: A61K31/5377 ,  A61K9/20 ,  A61K9/00 ,  A61K9/28

Abstract: The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).