公开(公告)号：US20190388420A1

公开(公告)日：2019-12-26

申请号：US16465277

申请日：2018-02-06

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yoichi Ozawa ,  Yusaku Hori ,  Kazuhiko Yamada ,  Hiroshi Kamiyama ,  Masahiro Matsuki

IPC: A61K31/4985 ,  A61P35/00

Abstract: Provided is a pharmaceutical composition for treating a tumor, which is used in combination therapy of lenvatinib and (6S,9aS)—N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.

公开(公告)号：US11925639B2

公开(公告)日：2024-03-12

申请号：US16465277

申请日：2018-02-06

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yoichi Ozawa ,  Yusaku Hori ,  Kazuhiko Yamada ,  Hiroshi Kamiyama ,  Masahiro Matsuki

IPC: A61K31/4985 ,  A61K31/53 ,  A61P35/00

CPC classification number: A61K31/4985 ,  A61K31/53 ,  A61P35/00

Abstract: Provided is a pharmaceutical composition for treating a tumor, which is used in combination therapy of lenvatinib and (6S,9aS)—N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.