公开(公告)号：US20210324056A1

公开(公告)日：2021-10-21

申请号：US17250448

申请日：2019-07-23

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Johan LUTHMAN ,  Chad J. SWANSON ,  Yong ZHANG ,  Shobha DHADDA ,  Jinping WANG ,  Lynn KRAMER

IPC: C07K16/18 ,  A61K31/542 ,  A61P25/28

Abstract: Provided herein are methods of reducing clinical decline in a subject having early Alzheimer's disease, methods of converting an amyloid positive subject having early Alzheimer's disease to amyloid negative, methods of reducing brain amyloid level in a subject, and methods of preventing Alzheimer's disease, the methods comprising administering a composition comprising a therapeutically effective amount of at least one anti-Aβ protofibril antibody. In some embodiments, the subject is ApoE4-positive. In some embodiments, the at least one anti-Aβ protofibril antibody is BAN2401.