公开(公告)号：US20230183328A1

公开(公告)日：2023-06-15

申请号：US17906660

申请日：2021-03-19

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Nobuo YOSHIDA ,  Naomi SAKURAMOTO ,  Takahisa SAKAGUCHI ,  Hirokazu KITO ,  Takahiro OZAWA ,  Anjali JOSHI ,  Yung Yueh HSU ,  Pierre SOUILLAC

IPC: C07K16/18 ,  A61K31/133 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61K31/133 ,  A61P25/28

Abstract: Provided herein are aqueous pharmaceutical formulations comprising high concentrations of anisolated anti-Aβ protofibril antibody or a fragment thereof that binds to human Aβ protofibrils, such as BAN2401, arginine, polysorbate 80, and a pharmaceutically acceptable buffer.