公开(公告)号：US20240352109A1

公开(公告)日：2024-10-24

申请号：US18688264

申请日：2022-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Akihiko Koyama ,  Chad Swanson ,  Michio KANEKIYO ,  Michael IRIZARRY ,  Lynn Kramer ,  June KAPLOW ,  David VERBEL ,  Shobha DHADDA ,  Pallavi SACHDEV ,  Larisa REYDERMAN ,  Ishani Landry ,  Seiichi HAYATO ,  Robert Gordon

IPC: C07K16/18 ,  A61K9/00 ,  A61K39/00 ,  A61K47/18 ,  A61K47/26 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61K9/0019 ,  A61K47/183 ,  A61K47/26 ,  A61P25/28 ,  A61K2039/505 ,  A61K2039/545

Abstract: Disclosed herein are methods of treating Alzheimer's disease, methods of reducing clinical decline in a subject having early Alzheimer's disease, methods of reducing brain amyloid level in a subject, methods of converting a subject from amyloid positive to amyloid negative, methods of preventing Alzheimer's disease, the methods comprising subcutaneously administering an anti-Aβ protofibril antibody.