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公开(公告)号：US20180303817A1
公开(公告)日：2018-10-25
申请号：US15771193
申请日：2016-12-15
发明人： Saori Miyano , Yuji Yamamoto , Takayuki Nakagawa
IPC分类号： A61K31/4545 , A61P35/04
CPC分类号： A61K31/4545 , A61P35/04
摘要： The present application discloses a therapeutic agent for breast cancer, comprising 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide or a pharmacologically acceptable salt thereof.
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公开(公告)号：US20230172924A1
公开(公告)日：2023-06-08
申请号：US18008304
申请日：2021-07-29
发明人： Satoshi KAWANO , Saori Miyano , Kyoko NISHIBATA , Sayo FUKUSHIMA
IPC分类号： A61K31/4545 , A61K31/565 , A61K31/4196 , A61K31/566 , A61P35/00
CPC分类号： A61K31/4545 , A61K31/565 , A61K31/4196 , A61K31/566 , A61P35/00
摘要： Disclosed is a therapeutic agent for breast cancer, said therapeutic agent comprising 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide or a pharmacologically acceptable salt thereof that is to be administered in combination with an estrogen receptor antagonist or an aromatase inhibitor.
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公开(公告)号：US20210333281A1
公开(公告)日：2021-10-28
申请号：US17282218
申请日：2019-10-02
IPC分类号： G01N33/574 , A61K31/47 , A61P35/00 , C12Q1/6886
摘要： Biomarkers are provided that predict whether a subject having a hepatocellular carcinoma is responsive to a therapy comprising soratenib or a pharmaceutically acceptable salt thereof. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for and treating a subject having, suspected of having, or at risk of developing a hepatocellular carcinoma.
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公开(公告)号：US11219619B2
公开(公告)日：2022-01-11
申请号：US16970683
申请日：2019-03-26
发明人： Atsumi Yamaguchi , Hajime Shimizu , Satoshi Goda , Saori Miyano
IPC分类号： A61K31/4545 , A61K45/06
摘要： Disclosed is a therapeutic agent for hepatocellular carcinoma, comprising 5-((2-(4-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide or a pharmacologically acceptable salt thereof.
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公开(公告)号：US20200375970A1
公开(公告)日：2020-12-03
申请号：US16970683
申请日：2019-03-26
发明人： Atsumi Yamaguchi , Hajime Shimizu , Satoshi Goda , Saori Miyano
IPC分类号： A61K31/4545 , A61K45/06
摘要： Disclosed is a therapeutic agent for hepatocellular carcinoma, comprising 5-((2-(4-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide or a pharmacologically acceptable salt thereof.
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