公开(公告)号：US20180282312A1

公开(公告)日：2018-10-04

申请号：US16000539

申请日：2018-06-05

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Kevin Wayne KUNTZ ,  Hyeong Wook CHOI ,  Steven MATHIEU ,  Kristen SANDERS ,  Arani CHANDA

IPC: C07D405/12 ,  A61K31/5377 ,  C07D413/12

Abstract: Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.

公开(公告)号：US20170143729A1

公开(公告)日：2017-05-25

申请号：US15199522

申请日：2016-06-30

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Kevin Wayne KUNTZ ,  Kuan-Chun HUANG ,  Hyeong Wook CHOI ,  Kristen SANDERS ,  Steven MATHIEU ,  Arani CHANDA ,  Frances FANG

IPC: A61K31/5377

CPC classification number: A61K31/5377 ,  C07D405/12

Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

公开(公告)号：US20210137936A1

公开(公告)日：2021-05-13

申请号：US17032432

申请日：2020-09-25

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Kevin Wayne KUNTZ ,  Kuan-Chun HUANG ,  Hyeong Wook CHOI ,  Kristen SANDERS ,  Steven MATHIEU ,  Arani CHANDA ,  Francis FANG

IPC: A61K31/5377 ,  C07D405/12

Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

公开(公告)号：US20210017163A1

公开(公告)日：2021-01-21

申请号：US16891427

申请日：2020-06-03

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Kevin Wayne KUNTZ ,  Hyeong Wook CHOI ,  Steven MATHIEU ,  Kristen SANDERS ,  Arani CHANDA

IPC: C07D405/12 ,  A61K31/5377 ,  C07D413/12

Abstract: Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.

公开(公告)号：US20170240560A1

公开(公告)日：2017-08-24

申请号：US15501658

申请日：2015-08-04

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. FANG ,  Hyeong-Wook CHOI ,  Silvio CAMPAGNA ,  Steven MATHIEU

IPC: C07D493/22 ,  C07D313/00 ,  C07D493/08 ,  C07B57/00

CPC classification number: C07D493/22 ,  C07B57/00 ,  C07D313/00 ,  C07D493/08 ,  C07D493/18

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

公开(公告)号：US20200055866A1

公开(公告)日：2020-02-20

申请号：US16521691

申请日：2019-07-25

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. FANG ,  Hyeong-wook CHOI ,  Silvio CAMPAGNA ,  Steven MATHIEU

IPC: C07D493/22 ,  C07D493/18 ,  C07D493/08 ,  C07D313/00 ,  C07B57/00

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

公开(公告)号：US20190269692A1

公开(公告)日：2019-09-05

申请号：US16270752

申请日：2019-02-08

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Kevin Wayne KUNTZ ,  Kuan-Chun HUANG ,  Hyeong Wook CHOI ,  Kristen SANDERS ,  Steven MATHIEU ,  Arani CHANDA ,  Francis FANG

IPC: A61K31/5377 ,  C07D405/12

Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

公开(公告)号：US20180186810A1

公开(公告)日：2018-07-05

申请号：US15906401

申请日：2018-02-27

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. FANG ,  Hyeong-Wook CHOI ,  Silvio CAMPAGNA ,  Steven MATHIEU

IPC: C07D493/22 ,  C07D493/18 ,  C07D493/08 ,  C07B57/00 ,  C07D313/00

CPC classification number: C07D493/22 ,  C07B57/00 ,  C07D313/00 ,  C07D493/08 ,  C07D493/18

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

公开(公告)号：US20160237068A1

公开(公告)日：2016-08-18

申请号：US15029848

申请日：2014-10-15

Applicant: EPIZYME, INC. ,  EISAI R&D MANAGEMENT CO., LTD.

Inventor： Kevin W. KUNTZ ,  Hyeong-wook CHOI ,  Steven MATHIEU ,  Kristen SANDERS ,  Arani CHANDA

IPC: C07D405/12

CPC classification number: C07D405/12 ,  A61K31/5377 ,  C07B2200/13 ,  C07D413/12

Abstract: Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.

Abstract translation: 本文提供了新的固体形式的N - （（4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基）甲基）-5-（乙基（四氢-2H-吡喃-4-基）氨基 ）-4-甲基-4' - （吗啉代甲基） - [1,1'-联苯] -3-甲酰胺盐酸盐，以及相关的组合物和方法。