公开(公告)号：US10261092B2

公开(公告)日：2019-04-16

申请号：US14696904

申请日：2015-04-27

申请人： Elanco Tiergesundheit AG

发明人： Thomas Plocher ,  Manuel Campos ,  Richard Harland ,  Todd Johnson ,  Trent Harbison ,  Dan Keil

IPC分类号： G01N33/50 ,  G01N33/68 ,  A61K39/102 ,  A61K39/00

摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.