公开(公告)号：US09000174B2

公开(公告)日：2015-04-07

申请号：US11665345

申请日：2005-10-14

申请人： Elfrida R. Benjamin ,  Zhengming Chen ,  Deyou Sha ,  Laykea Tafesse ,  Samuel F. Victory ,  John W. F. Whitehead

发明人： Elfrida R. Benjamin ,  Zhengming Chen ,  Deyou Sha ,  Laykea Tafesse ,  Samuel F. Victory ,  John W. F. Whitehead

IPC分类号： C07D211/58 ,  A61K31/4545 ,  A61K31/4468 ,  C07D401/06 ,  C07D211/96

CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D211/96

摘要： The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

公开(公告)号：US20090105249A1

公开(公告)日：2009-04-23

申请号：US11665345

申请日：2005-10-14

申请人： Elfrida R. Benjamin ,  Zhengming Chen ,  Deyou Sha ,  Laykea Tafesse ,  Samuel F. Victory ,  John W.F. Whitehead ,  Xiaoming Zhou

发明人： Elfrida R. Benjamin ,  Zhengming Chen ,  Deyou Sha ,  Laykea Tafesse ,  Samuel F. Victory ,  John W.F. Whitehead ,  Xiaoming Zhou

IPC分类号： A61K31/5377 ,  C07D211/58 ,  A61K31/4468 ,  A61K31/4545 ,  C12Q1/02 ,  C07D401/06 ,  C07D413/02

CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D211/96

摘要： The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及式（I）的哌啶基化合物或其药学上可接受的盐，前药或溶剂化物，其中R1-R3和Z定义如说明书所述。 本发明还涉及可用于鉴定N型钙通道调节剂或阻断剂的化合物的测定法。 本发明还涉及式（I）的化合物和通过上述测定法鉴定的化合物，以及这些化合物用于治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症的用途 。 本发明的化合物特别适用于治疗疼痛。