公开(公告)号：US20240082414A1

公开(公告)日：2024-03-14

申请号：US18312653

申请日：2023-05-05

申请人： Eli Lilly and Company

发明人： Grace Chao ,  Joshua R Clayton ,  Jordan Scott Crampton ,  Yiqing Feng ,  Donmienne Doen Mun Leung ,  Songqing Na ,  Kristin Paige Newburn ,  Scott Charles Potter ,  Bharathi Ramamurthy ,  David John Stokell ,  Jacqueline M. Wurst ,  Jianghuai Xu

IPC分类号： A61K47/68 ,  A61K31/58 ,  A61P19/02 ,  C07K16/24

CPC分类号： A61K47/6803 ,  A61K31/58 ,  A61P19/02 ,  C07K16/241

摘要： The present disclosure provides human tumor necrosis factor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of autoimmune and inflammatory diseases.

公开(公告)号：US20230192837A1

公开(公告)日：2023-06-22

申请号：US18054284

申请日：2022-11-10

申请人： Eli Lilly and Company

发明人： Grace Chao ,  Yiqing Feng ,  Donmienne Doen Mun Leung ,  Songqing Na ,  Bharathi Ramamurthy ,  Jianghuai Xu

IPC分类号： C07K16/24 ,  A61K47/68 ,  A61P37/06

CPC分类号： C07K16/241 ,  A61K47/6845 ,  A61P37/06 ,  A61K2039/505

摘要： The present disclosure relates to antibodies that specifically bind soluble and membrane forms of human TNFα, compositions comprising such TNFα antibodies, and methods of using such TNFα antibodies and compositions.