公开(公告)号：US20220017496A1

公开(公告)日：2022-01-20

申请号：US17478080

申请日：2021-09-17

申请人： Eli Lilly and Company

发明人： David Andrew COATES ,  Timothy Barrett DURHAM ,  Richard Duane JOHNSTON ,  Steven Marc MASSEY ,  Patrick Gianpietro SPINAZZE ,  Douglas Richard STACK ,  James Lee TOTH

IPC分类号： C07D403/14 ,  A61P1/16 ,  A61P3/10 ,  A61P13/12 ,  A61P9/04

摘要： The present invention provides a compound of Formula I. or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

公开(公告)号：US20150344468A1

公开(公告)日：2015-12-03

申请号：US14718129

申请日：2015-05-21

申请人： Eli Lilly and Company

发明人： Kevin Matthew GARDINIER ,  Douglas Linn GERNERT ,  Patric James HAHN ,  Sean Patrick HOLLINSHEAD ,  Albert KHILEVICH ,  Daniel Ray MAYHUGH ,  Paul Leslie ORNSTEIN ,  Warren Jaye PORTER ,  Jon Kevin REEL ,  Jeffrey Michael SCHKERYANTZ ,  Patrick Gianpietro SPINAZZE ,  Freddie Craig STEVENS ,  Jeffrey Michael WITKIN

IPC分类号： C07D417/14

CPC分类号： C07D417/14 ,  A61K31/195 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

摘要： A TARP γ8 dependant AMPA receptor antagonist of the formula: wherein X is CH or N; A is and R1 is as defined herein; its pharmaceutically acceptable salts, uses, and methods for its preparation are described.

摘要翻译： TARPγ8依赖性AMPA受体拮抗剂，其具有下式：其中X是CH或N; A是且R 1如本文所定义; 描述了其药学上可接受的盐，用途及其制备方法。