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公开(公告)号:US20090226420A1
公开(公告)日:2009-09-10
申请号:US12084759
申请日:2006-11-10
IPC分类号: C12Q1/68 , A61K39/395 , A61P9/00
CPC分类号: C12Q1/6883 , C12Q2600/156
摘要: The invention relates to predicting, or aiding in predicting, which individuals are at risk of developing coronary artery disease. The invention provides a method for identifying an individual who has an altered risk for developing CAD. The invention further relates to methods of reducing the likelihood that a subject will develop CAD. The invention further provides reagents, nucleic acids and kits comprising nucleic acids containing a polymorphism in a CAD-determinative gene.
摘要翻译: 本发明涉及预测或协助预测哪些个体处于发展冠状动脉疾病的风险中。 本发明提供了一种用于识别具有改变发展CAD风险的个体的方法。 本发明还涉及减少受试者发展CAD的可能性的方法。 本发明还提供了试剂,核酸和试剂盒,其包含在CAD-决定基因中含有多态性的核酸。
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公开(公告)号:US20070148661A1
公开(公告)日:2007-06-28
申请号:US11458228
申请日:2006-07-18
CPC分类号: C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要: The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.
摘要翻译: LSAMP基因可用于心血管疾病风险评估,特别是左主干疾病。 归因于LSAMP的遗传风险增加了已知的心血管疾病危险因素。 评估LSAMP的风险可以早日开始预防和治疗策略。 鉴于与左主干病相关的明显临床风险,这种风险评估应显着降低发病率和死亡率。
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公开(公告)号:US20110070583A1
公开(公告)日:2011-03-24
申请号:US12806690
申请日:2010-08-19
申请人: Jeffery M. Vance , Pascal Goldschmidt , Elizabeth Hauser , William Kraus , Margaret A. Pericak-Vance
发明人: Jeffery M. Vance , Pascal Goldschmidt , Elizabeth Hauser , William Kraus , Margaret A. Pericak-Vance
CPC分类号: C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要: The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.
摘要翻译: LSAMP基因可用于心血管疾病风险评估,特别是左主干疾病。 归因于LSAMP的遗传风险增加了已知的心血管疾病危险因素。 评估LSAMP的风险可以早日开始预防和治疗策略。 鉴于与左主干病相关的明显临床风险,这种风险评估应显着降低发病率和死亡率。
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