公开(公告)号：US20090105334A1

公开(公告)日：2009-04-23

申请号：US11442445

申请日：2006-05-26

申请人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

发明人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

IPC分类号： A61K31/27 ,  A61P25/06

CPC分类号： A61K31/27

摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

摘要翻译： 本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个 至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

公开(公告)号：US07087643B2

公开(公告)日：2006-08-08

申请号：US10869406

申请日：2004-06-16

申请人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

发明人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

IPC分类号： A00N47/10 ,  A61K31/27

CPC分类号： A61K31/27

摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1–C4 alkyl; wherein C1–C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1–C4 alkyl, C1–C4 alkoxy, amino, nitro and cyano).

摘要翻译： 本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个 至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4各自独立地选自氢和C 1个C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1〜 C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。