公开(公告)号：US20250034200A1

公开(公告)日：2025-01-30

申请号：US18709395

申请日：2022-11-10

Applicant: Emory University

Inventor： Dennis Liotta ,  Russell Fritzemeier ,  Alet van der Westhuyzen ,  Luke E. Hodson

IPC: C07J41/00 ,  A61K31/57 ,  A61K31/58 ,  A61P25/00 ,  C07J43/00

Abstract: Prodrugs of neurosteroid analogs are disclosed. Pharmaceutical formulations containing the prodrugs are also disclosed, Additionally, methods of treating a condition, disorder, or disease using the prodrugs or their pharmaceutical formulations are disclosed. Exemplary conditions, disorders, and diseases relevant to this disclosure include stroke, subarachnoid hemorrhage, cerebral ischemia, cerebral vasospasm, hypoxia, CNS injury, concussion, traumatic brain injury, depression, postpartum depression, epilepsy, seizure disorder, and neurodegenerative disease.

公开(公告)号：US20250026781A1

公开(公告)日：2025-01-23

申请号：US18709256

申请日：2022-11-10

Applicant: Emory University

Inventor： Dennis Liotta ,  Russell Fritzemeier ,  Alet van der Westhuyzen ,  Luke E. Hodson ,  Gouthami Pashikanti

IPC: C07J41/00 ,  A61K31/57 ,  A61K31/58 ,  C07J43/00

Abstract: Prodrugs of neurosteroid analogs are disclosed. Pharmaceutical formulations containing the prodrugs are also disclosed. Additionally, methods of treating a condition, disorder, or disease using the prodrugs or their pharmaceutical formulations are disclosed. Exemplary conditions, disorders, and diseases relevant to this disclosure include stroke, subarachnoid hemorrhage, cerebral ischemia, cerebral vasospasm, hypoxia, CNS injury, concussion, traumatic brain injury, depression, postpartum depression, epilepsy, seizure disorder, essential tremor, fragile X syndrome, and neurodegenerative disease.