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1.发明授权Conjugates of GM-CSF and IL-7, compositions and methods related thereto 有权GM-CSF和IL-7的结合物，与其相关的组合物和方法公开(公告)号：US09375465B2
公开(公告)日：2016-06-28
申请号：US14355673
申请日：2012-11-13
CPC分类号： A61K39/39 , A61K35/14 , A61K38/00 , A61K38/193 , A61K38/2046 , A61K39/0005 , A61K39/0011 , A61K39/245 , A61K2039/5158 , A61K2039/55522 , A61K2039/55527 , A61K2039/572 , C07K14/535 , C07K14/5418 , C07K2319/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.
摘要翻译： 在某些实施方案中，本公开涉及包含GM-CSF和IL-7并且与其相关的缀合物，例如增强适应性免疫系统。 通常，GM-CSF和IL-7通过聚合物接头例如多肽连接。 在某些实施方案中，本公开涉及编码这些多肽缀合物的核酸，包含编码多肽缀合物的核酸的载体和包含这些载体的蛋白质表达系统，例如感染性病毒颗粒和包含这种核酸的宿主细胞。
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公开(公告)号：US20180289799A1
公开(公告)日：2018-10-11
申请号：US16007392
申请日：2018-06-13
IPC分类号： A61K39/39 , C07K14/535 , A61K38/19 , A61K38/20 , A61K39/00 , C07K14/54 , A61K35/14 , A61K39/245 , A61K38/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.
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公开(公告)号：US20230053010A1
公开(公告)日：2023-02-16
申请号：US17682781
申请日：2022-02-28
IPC分类号： A61K39/39 , C07K14/535 , C07K14/54 , A61K39/00 , A61K35/14 , A61K38/19 , A61K38/20 , A61K39/245
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically, the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such nucleic acids.
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公开(公告)号：US09999666B2
公开(公告)日：2018-06-19
申请号：US15157647
申请日：2016-05-18
IPC分类号： A61K38/19 , A61K39/39 , C07K14/535 , C07K14/54 , A61K39/00 , A61K35/14 , A61K38/20 , A61K39/245 , A61K38/00
CPC分类号： A61K39/39 , A61K35/14 , A61K38/00 , A61K38/193 , A61K38/2046 , A61K39/0005 , A61K39/0011 , A61K39/245 , A61K2039/5158 , A61K2039/55522 , A61K2039/55527 , A61K2039/572 , C07K14/535 , C07K14/5418 , C07K2319/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.
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公开(公告)号：US20160250326A1
公开(公告)日：2016-09-01
申请号：US15157647
申请日：2016-05-18
IPC分类号： A61K39/39 , A61K38/20 , A61K39/245 , A61K38/19
CPC分类号： A61K39/39 , A61K35/14 , A61K38/00 , A61K38/193 , A61K38/2046 , A61K39/0005 , A61K39/0011 , A61K39/245 , A61K2039/5158 , A61K2039/55522 , A61K2039/55527 , A61K2039/572 , C07K14/535 , C07K14/5418 , C07K2319/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.
摘要翻译： 在某些实施方案中，本公开涉及包含GM-CSF和IL-7并且与其相关的缀合物，例如增强适应性免疫系统。 通常，GM-CSF和IL-7通过聚合物接头例如多肽连接。 在某些实施方案中，本公开涉及编码这些多肽缀合物的核酸，包含编码多肽缀合物的核酸的载体和包含这些载体的蛋白质表达系统，例如感染性病毒颗粒和包含这种核酸的宿主细胞。
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6.发明申请公开(公告)号：US20140369956A1
公开(公告)日：2014-12-18
申请号：US14355673
申请日：2012-11-13
IPC分类号： A61K39/00 , C07K14/54 , C07K14/535 , A61K35/14
CPC分类号： A61K39/39 , A61K35/14 , A61K38/00 , A61K38/193 , A61K38/2046 , A61K39/0005 , A61K39/0011 , A61K39/245 , A61K2039/5158 , A61K2039/55522 , A61K2039/55527 , A61K2039/572 , C07K14/535 , C07K14/5418 , C07K2319/00
摘要： In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.
摘要翻译： 在某些实施方案中，本公开涉及包含GM-CSF和IL-7并且与其相关的缀合物，例如增强适应性免疫系统。 通常，GM-CSF和IL-7通过聚合物接头例如多肽连接。 在某些实施方案中，本公开涉及编码这些多肽缀合物的核酸，包含编码多肽缀合物的核酸的载体和包含这些载体的蛋白质表达系统，例如感染性病毒颗粒和包含这种核酸的宿主细胞。
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