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公开(公告)号：US20170319502A1
公开(公告)日：2017-11-09
申请号：US15656142
申请日：2017-07-21
IPC分类号： A61K9/48 , A61K9/00 , A61K47/14 , A61K47/12 , A61K47/10 , A61K31/7036 , A61K31/7012 , A61K31/65 , A61K31/64 , A61K31/397 , A61K31/351 , A61K31/216 , A61K31/122 , A61K47/18
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
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公开(公告)号：US20170056328A1
公开(公告)日：2017-03-02
申请号：US15353213
申请日：2016-11-16
IPC分类号： A61K9/48 , A61K31/7036 , A61K31/351 , A61K9/00 , A61K31/65
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
摘要翻译： 本发明提供适于口服给药的药物组合物和治疗有此需要的受试者的方法。 本发明的药物组合物提高了分类为BCS II类，BCS III类或BCS类IV类的至少一种化合物的生物利用度。
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公开(公告)号：US09744140B2
公开(公告)日：2017-08-29
申请号：US15353213
申请日：2016-11-16
IPC分类号： A61K31/65 , A61K31/351 , A61K31/7036 , A61K9/52 , A61K9/48 , A61K47/18 , A61K31/216 , A61K47/12 , A61K47/10 , A61K47/14 , A61K31/122 , A61K31/397 , A61K31/64 , A61K31/7012 , A61K9/00
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
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公开(公告)号：US09526785B2
公开(公告)日：2016-12-27
申请号：US15184971
申请日：2016-06-16
IPC分类号： A61K31/65 , A61K31/351 , A61K31/7036 , A61K9/52 , A61K47/12 , A61K9/00 , A61K47/18 , A61K31/216
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
摘要翻译： 本发明提供适于口服给药的药物组合物和治疗有此需要的受试者的方法。 本发明的药物组合物提高了分类为BCS II类，BCS III类或BCS类IV类的至少一种化合物的生物利用度。
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公开(公告)号：US20160296624A1
公开(公告)日：2016-10-13
申请号：US15184971
申请日：2016-06-16
IPC分类号： A61K47/12 , A61K31/65 , A61K31/216 , A61K9/00 , A61K47/18 , A61K31/7036 , A61K31/351
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
摘要翻译： 本发明提供适于口服给药的药物组合物和治疗有此需要的受试者的方法。 本发明的药物组合物提高了分类为BCS II类，BCS III类或BCS类IV类的至少一种化合物的生物利用度。
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公开(公告)号：US09457086B2
公开(公告)日：2016-10-04
申请号：US14197405
申请日：2014-03-05
IPC分类号： A61K31/65 , A61K31/351 , A61K31/7036 , A61K9/52 , A61K47/18 , A61K31/216 , A61K47/12 , A61K47/10 , A61K47/14 , A61K9/48 , A61K31/122 , A61K31/397 , A61K31/64 , A61K31/7012 , A61K9/00
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides solid oral dosage forms and methods of treating subjects in need thereof. The solid oral dosage forms of the present invention provide a mixture including at least one compound classified as BCS Class II, BCS Class III or BCS Class IV, where the compound does not include a peptide bond in the compound's molecular structure; an absorption enhancer; and coated organic acid particles; an enteric coating; and a water soluble barrier positioned between the mixture and the enteric coating.
摘要翻译： 本发明提供了治疗有需要的受试者的固体口服剂型和方法。 本发明的固体口服剂型提供了包含至少一种分类为BCS II类，BCS III类或BCS类IV类的化合物的混合物，其中化合物在化合物的分子结构中不包括肽键; 吸收增强剂 和涂布的有机酸颗粒; 肠溶衣; 和位于混合物和肠溶衣之间的水溶性屏障。
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公开(公告)号：US20140255479A1
公开(公告)日：2014-09-11
申请号：US14197405
申请日：2014-03-05
IPC分类号： A61K47/18 , A61K31/351 , A61K47/14 , A61K31/216 , A61K47/12 , A61K47/10 , A61K31/65 , A61K31/7036
CPC分类号： A61K9/4891 , A61K9/0019 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/122 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/64 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/186
摘要： The present invention provides pharmaceutical compositions suitable for oral and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
摘要翻译： 本发明提供适于口服的药物组合物和治疗有此需要的受试者的方法。 本发明的药物组合物提高了分类为BCS II类，BCS III类或BCS类IV类的至少一种化合物的生物利用度。
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