公开(公告)号：US11253608B2

公开(公告)日：2022-02-22

申请号：US15991745

申请日：2018-05-29

Applicant: EpicentRx, Inc.

Inventor： Christopher Larson ,  Bryan Oronsky ,  Tony R. Reid

IPC: C12N15/85 ,  A61K47/68 ,  A61P35/00 ,  A61K47/69 ,  C12N7/04 ,  A61K48/00 ,  C12N15/62 ,  C12N7/02 ,  C12N15/86

Abstract: Disclosed herein are recombinant adenoviruses with one or more nucleotide sequences inserted between two viral transcription units, formulations comprising the recombinant adenoviruses, and methods of treatment using the recombinant adenoviruses. In some embodiments, the one or more nucleotide sequences are inserted in an IX-E2 insertion site and/or an L5-E4 insertion site.

公开(公告)号：US12280123B2

公开(公告)日：2025-04-22

申请号：US17575488

申请日：2022-01-13

Applicant: EpicentRx, Inc.

Inventor： Christopher Larson ,  Bryan Oronsky ,  Tony R. Reid

IPC: A61K35/761 ,  A61K47/68 ,  A61K47/69 ,  A61K48/00 ,  A61P35/00 ,  C12N7/02 ,  C12N7/04 ,  C12N15/62 ,  C12N15/85 ,  C12N15/86

Abstract: Disclosed herein are recombinant adenoviruses with one or more nucleotide sequences inserted between two viral transcription units, formulations comprising the recombinant adenoviruses, and methods of treatment using the recombinant adenoviruses. In some embodiments, the one or more nucleotide sequences are inserted in an IX-E2 insertion site and/or an L5-E4 insertion site.