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1.发明授权公开(公告)号：US11008287B2
公开(公告)日：2021-05-18
申请号：US16341538
申请日：2017-10-13
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: C07D205/04
Abstract: The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze-tidin-1-yl)-2-oxoethyl)sulfinyl)-D-alanine and variants thereof.
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公开(公告)号：US10342778B1
公开(公告)日：2019-07-09
申请号：US15298735
申请日：2016-10-20
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: A61N5/10 , A61K31/397 , A61K9/00 , A61K31/495
Abstract: The invention provides therapeutic methods and kits for treating brain metastases using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and optionally an additional anti-cancer agent.
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公开(公告)号：US20220054480A1
公开(公告)日：2022-02-24
申请号：US17223422
申请日：2021-04-06
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: A61K31/495 , A61K31/397 , A61K9/00 , A61K31/4745
Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.
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4.发明申请公开(公告)号：US20190307723A1
公开(公告)日：2019-10-10
申请号：US16069012
申请日：2017-01-11
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski , Scott Caroen
IPC: A61K31/397 , A61K35/14 , A61K9/00 , A61P35/00 , A61K47/10 , A61K47/18 , A61K31/727 , A61P35/02 , A61K31/194
Abstract: The invention provides compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone (ABDNAZ), including formulations containing autologous whole blood and ABDNAZ that can be rapidly administered to a patient by intravenous infusion without any significant pain at the site of infusion.
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公开(公告)号：US09468625B2
公开(公告)日：2016-10-18
申请号：US14849783
申请日：2015-09-10
Applicant: EpicentRx, Inc.
Inventor： Jan Scicinski , Bryan T. Oronsky
IPC: A61K31/397 , C07D205/04 , A61K31/19 , A61K31/198 , A61K31/215 , A61K31/337 , A61K45/06 , A61N5/10 , A61K38/05
CPC classification number: A61K31/397 , A61K31/19 , A61K31/198 , A61K31/215 , A61K31/337 , A61K38/05 , A61K45/06 , A61N5/10 , C07D205/04
Abstract: The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof.
Abstract translation: 本发明提供有机硫醚化合物，含有这些化合物的组合物，分离的有机硫醚化合物和使用这些化合物和组合物治疗患者癌症的方法。 本文所述的示例性有机亚硫醚化合物包括2-（3,3-二硝基吖丁啶-1-基）-2-氧代乙基硫醚及其变体。
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Patent Agency Ranking
公开(公告)号：US11576895B2
公开(公告)日：2023-02-14
申请号：US16069012
申请日：2017-01-11
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski , Scott Caroen
IPC: A61K31/397 , A61P35/02 , A61P35/00 , A61K9/00 , A61K31/194 , A61K31/727 , A61K35/14 , A61K47/10 , A61K47/18 , A61K47/46 , A61K9/08
Abstract: The invention provides compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone (ABDNAZ), including formulations containing autologous whole blood and ABDNAZ that can be rapidly administered to a patient by intravenous infusion without any significant pain at the site of infusion.
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公开(公告)号：US11160784B1
公开(公告)日：2021-11-02
申请号：US16456396
申请日：2019-06-28
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: A61N5/10 , A61K31/397 , A61K31/495 , A61K9/00
Abstract: The invention provides therapeutic methods and kits for treating brain metastases using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and optionally an additional anti-cancer agent.
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8.发明申请公开(公告)号：US20200157047A1
公开(公告)日：2020-05-21
申请号：US16341538
申请日：2017-10-13
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: C07D205/04
Abstract: The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze-tidin-1-yl)-2-oxoethyl)sulfinyl)-D-alanine and variants thereof.
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公开(公告)号：US10543208B2
公开(公告)日：2020-01-28
申请号：US15989862
申请日：2018-05-25
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: A61K31/495 , A61K9/00 , A61K31/397 , A61K31/4745 , A61N5/10
Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.
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公开(公告)号：US20190125742A1
公开(公告)日：2019-05-02
申请号：US15989862
申请日：2018-05-25
Applicant: EpicentRx, Inc.
Inventor： Bryan T. Oronsky , Jan Scicinski
IPC: A61K31/495 , A61K9/00 , A61K31/397 , A61K31/4745
Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.
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